The Registry of Toxic Effects of Chemical Substances

1 - Propanol, 2,3 - epoxy -

RTECS #: UB4375000

CAS #: 556-52-5

UPDATE: May 2005 MW: 74.09 MF: C3H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2,3 - Epoxy - 1 - propanol (ACGIH:OSHA)
  2. 2,3 - Epoxypropanol
  3. 3 - Hydroxy - 1,2 - epoxypropane
  4. Epihydrin alcohol
  5. Glycide
  1. Glycidol
  2. Glycidol (ACGIH:OSHA)
  3. Glycidyl alcohol
  4. Methanol, oxiranyl -
  5. NCI - C55549


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		2 mg/24 hour severe 85JCAE -,769,1986
skin
rabbit 		558 mg/3 day moderate AMIHAB 14,250,1956
skin
rabbit 		100 mg/24 hour moderate 85JCAE -,769,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 12,500 µg/L NTPTR* NTP-TR-374,1990
cytogenetic analysis human lymphocyte 400 µmol/L MUREAV 91,243,1981
cytogenetic analysis intraperitoneal
rat 		320 mg/kg FCTOD7 22,665,1984
cytogenetic analysis oral
rat 		600 mg/kg FCTOD7 22,665,1984
DNA repair Escherichia coli 10 gm/L MUREAV 130,141,1984
mutation in microorganisms Escherichia coli 500 µmol/L (-enzymatic activation step) TOLED5 4,103,1979
mutation in microorganisms Klebsiella pneumoniae 200 µmol/L (-enzymatic activation step) MUREAV 89,269,1981
mutation in microorganisms Neurospora crassa 500 mmol/L (-enzymatic activation step) GENTAE 40,890,1955
mutation in microorganisms Salmonella typhimurium 3 µg/plate (+enzymatic activation step) MUREAV 172,105,1986
gene conversion and mitotic recombination Saccharomyes cerevisiae 2,500 ppm JJIND8 62,901,1979
mutation in mammalian somatic cells hamster lung 1 µmol/L CRNGDP 11,497,1990
mutation in mammalian somatic cells mouse lymphocyte 1,250 µg/kg NTPTR* NTP-TR-374,1990
morphological transform hamster embryo 10 µg/L IJCNAW 19,642,1977
morphological transform mouse fibroblast 0.1 pph/21 day (-enzymatic activation step) EMMUEG 37,231,2001
other mutation test systems Escherichia coli 1 mmol/L MUREAV 231,205,1990
sister chromatid exchange hamster ovary 10,100 µg/L NTPTR* NTP-TR-374,1990
sister chromatid exchange hamster lung 1,250 µmol/L MUREAV 249,55,1991
sister chromatid exchange human lymphocyte 50 µmol/L MUREAV 91,243,1981
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		3,690 ppm NTPTR* NTP-TR-374,1990
heritable translocation test oral
Drosophila melanogaster 		1,230 ppm NTPTR* NTP-TR-374,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 500 mg/kg (5 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) BCSTB5 1,523,1973
oral
mouse 		lowest published toxic dose: 2 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JTEHD6 9,87,1982
oral
mouse 		lowest published toxic dose: 6,825 mg/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTPTR* NTP-TR-374,1990
oral
rat 		lowest published toxic dose: 180 mg/kg (12 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) NATUAS 226,87,1970
oral
rat 		lowest published toxic dose: 18,200 mg/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		NTPTR* NTP-TR-374,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 25,750 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors 		NTPTR* NTP-TR-374,1990
oral
mouse 		lowest published toxic dose: 12,875 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors 		NTIS** PB90-259094
oral
mouse 		lowest published toxic dose: 12,875 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Skin and Appendages: Tumors 		NTIS** PB90-259094
oral
rat 		lowest published toxic dose: 38,625 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors 		NTPTR* NTP-TR-374,1990
oral
rat 		lowest published toxic dose: 19,312.5 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Skin and Appendages: Tumors 		NTIS** PB90-259094
oral
rat 		lowest published toxic dose: 19,312.5 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors 		NTIS** PB90-259094


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 450 ppm/4 hour Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes 		AMIHAB 14,250,1956
inhalation
rat 		lethal concentration (50 percent kill): 580 ppm/8 hour Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes 		AMIHAB 14,250,1956
intraperitoneal
mouse 		lethal dose (50 percent kill): 500 mg/kg N/R PSEBAA 35,98,1936
intraperitoneal
rat 		lethal dose (50 percent kill): 200 mg/kg N/R FCTXAV 19,347,1981
oral
mouse 		lethal dose (50 percent kill): 431 mg/kg N/R GTPZAB 24(3),42,1980
oral
rat 		lethal dose (50 percent kill): 420 mg/kg N/R FCTXAV 19,347,1981
skin
rabbit 		lethal dose (50 percent kill): 1,980 mg/kg N/R AMIHAB 14,250,1956


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 125 mg/m3/4 hour/17 week- intermittent Brain and Coverings: Recordings from specific areas of CNS GTPZAB 24(3),42,1980
inhalation
rat 		lowest published toxic concentration: 125 mg/m3/4 hour/17 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Other changes 		GTPZAB 24(3),42,1980
oral
mouse 		lowest published toxic dose: 9,600 mg/kg/16 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-374,1990
oral
mouse 		lowest published toxic dose: 27,300 mg/kg/13 week- intermittent Brain and Coverings: Demyelination

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-374,1990
oral
rat 		lowest published toxic dose: 9,600 mg/kg/16 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-374,1990
oral
rat 		lowest published toxic dose: 36,400 mg/kg/13 week- intermittent Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Other changes 		NTPTR* NTP-TR-374,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 77,564,2000


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (150 mg/m3) DTLVS* 3,121,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (150 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (150 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (150 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (150 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (75 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 25 ppm (76 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.2 ppm (1 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (150 mg/m3), short term exposure limit 75 ppm (225 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 25 ppm (75 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 50 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (75 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (150 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 25 ppm (75 mg/m3), KTV 50 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 25 ppm (75 mg/m3), KZG- week 50 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (150 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO GLYCIDOL-air 10 hour time-weighted average 25 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 35120;
Number of Industries 3;
Total Number of Facilities 88;
Number of Occupations 10;
Total Number of Employees Exposed 4,872;
Total Number of Female Employees Exposed 580


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Glycidol, 1608
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Carcinogenesis studies; on test (prechronic studies), October 2000


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264) V.1- 1916-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used as a chemical intermediate

NIOSH PROFILE (EPOXY COMPOUNDS), SRC, 2/82

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

 Click Here for Additional Information about RTECS