RTECS:UB7700000 The Registry of Toxic Effects of Chemical Substances

The Registry of Toxic Effects of Chemical Substances

2 - Propanol, 1 - methoxy -

RTECS #: UB7700000

CAS #: 107-98-2

UPDATE: February 2005 MW: 90.14 MF: C₄H₁₀O₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

1 - Methoxy - 2 - propanol

Dowanol 33B

Dowanol PM

Dowanol PM glycol ether

Dowtherm 209

Glycol ether PM

Methoxy ether of propylene glycol

Methyl proxitol

PGME

Poly - Solve MPM

Propasol solvent M

Propylene glycol methyl ether

Propylene glycol monomethyl ether

Propylene glycol monomethyl ether (ACGIH)

Propylenglykol - monomethylaether (German)

Ucar Solvent LM (Obs.)

alpha - Propylene glycol monomethyl ether

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
rabbit 500 mg/24 hour mild 85JCAE -,625,1986
skin
rabbit 500 mg open irritation test mild UCDS 11/15/1971

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 3,000 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FAATDF 4,784,1984
inhalation
rat lowest published toxic concentration: 3,000 ppm/6 hour (multigeneration) Reproductive: Other effects on female

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Physical TOSCF2 50,249,1999
oral
mouse lowest published toxic dose: 3.3 gm/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS #PB86170578
oral
mouse lowest published toxic dose: 3.3 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system NTIS #PB86170578
oral
mouse lowest published toxic dose: 3.3 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS #PB86170578
oral
mouse lowest published toxic dose: 115.5 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS #PB86170578
oral
rabbit lowest published toxic dose: 936 mg/kg (7-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system TOSCF2 71,217,2003

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE**
inhalation
guinea pig lowest published lethal concentration: 15,000 ppm/7 hour Behavioral: Sleep AMIHBC 9,509,1954
inhalation
human lowest published toxic concentration: 3,000 ppm Olfaction: Tumors

Behavioral: General anesthetic

Gastrointestinal: Nausea or vomiting NPIRI* 1,105,1974
inhalation
human lowest published toxic concentration: 2,580 mg/m³ Eye: Lacrimation VCVGK* -,169,1984
inhalation
human lowest published toxic concentration: 7,540 mg/m³ Eye: Conjunctiva irritation VCVGK* -,169,1984
inhalation
human lowest published toxic concentration: 830 mg/m³/1 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough VCVGK* -,170,1984
inhalation
mouse lowest published toxic concentration: 1,000 ppm Liver: Other changes TOXID9 72,178,2003
inhalation
mouse lowest published toxic concentration: 3,000 ppm Behavioral: Antianxiety TOXID9 72,178,2003
inhalation
rat lethal concentration (50 percent kill): 10,000 ppm/5 hour N/R NPIRI* 1,105,1974
inhalation
rat lowest published toxic concentration: 18,400 mg/m³ Behavioral: Alteration of classical conditioning VCVGK* -,169,1984
inhalation
rat lowest published toxic concentration: 1,000 ppm Liver: Other changes TOXID9 72,178,2003
inhalation
rat lowest published toxic concentration: 1,000 ppm Kidney, Ureter, and Bladder: Other changes TOXID9 72,178,2003
inhalation
rat lowest published toxic concentration: 3,000 ppm Behavioral: Antianxiety TOXID9 72,178,2003
inhalation
rabbit lowest published lethal concentration: 15,000 ppm/7 hour N/R AMIHBC 9,509,1954
intraperitoneal
mouse lethal dose : >500 mg/kg N/R CBCCT* 4,110,1952
intraperitoneal
rat lethal dose (50 percent kill): 3,720 mg/kg N/R 38MKAJ 2C,3977,1982
intravenous
dog lethal dose (50 percent kill): 2 gm/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea ARZNAD 22,569,1972
intravenous
mouse lethal dose (50 percent kill): 5,300 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea ARZNAD 22,569,1972
intravenous
rat lethal dose (50 percent kill): 4,200 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea ARZNAD 22,569,1972
intravenous
rabbit lethal dose (50 percent kill): 1,200 mg/kg N/R ARZNAD 22,569,1972
oral
dog lethal dose (50 percent kill): 5 gm/kg N/R ARZNAD 22,569,1972
oral
mouse lethal dose (50 percent kill): 11,700 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea ARZNAD 22,569,1972
oral
rat lowest published lethal dose: 3,739 mg/kg Eye: Chromodacryorrhea

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia NTIS** OTS0520402
oral
rat lethal dose (50 percent kill): 6,600 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: General anesthetic

Lung, Thorax, or Respiration: Dyspnea VCVGK* -,169,1984
oral
rabbit lethal dose (50 percent kill): 5,700 mg/kg N/R ARZNAD 22,569,1972
subcutaneous
rat lethal dose (50 percent kill): 7,800 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea ARZNAD 22,569,1972
subcutaneous
rabbit lethal dose (50 percent kill): 5 gm/kg N/R ARZNAD 22,569,1972
skin
rabbit lethal dose (50 percent kill): 13 gm/kg N/R NPIRI* 1,105,1974

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
guinea pig lowest published toxic concentration: 6,000 ppm/7 hour/16 week- intermittent Behavioral: General anesthetic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain AMIHBC 9,509,1954
inhalation
monkey lowest published toxic concentration: 10,000 ppm/4 hour/13 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain AMIHBC 9,509,1954
inhalation
mouse lowest published toxic concentration: 3,000 ppm/6 hour/11 day- intermittent Liver: Changes in liver weight TXAPA9 61,368,1981
inhalation
rat lowest published toxic concentration: 3,000 ppm/6 hour/11 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition TXAPA9 61,368,1981
inhalation
rat lowest published toxic concentration: 3,000 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight FAATDF 3,627,1983
inhalation
rat lowest published toxic concentration: 11,000 mg/m³/6 hour/9 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition VCVGK* -,170,1994
inhalation
rat lowest published toxic concentration: 2,200 mg/m³/12 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct VCVGK* -,170,1994
inhalation
rabbit lowest published toxic concentration: 3,000 ppm/6 hour/13 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases FAATDF 3,627,1983
multiple
human lowest published toxic dose: 100 ppm/3 hour/2 week- intermittent Olfaction: Other olfaction effects TOLED5 135,S30,2002
multiple
human lowest published toxic dose: 150 ppm/3 hour/2 week- intermittent Olfaction: Other olfaction effects

Eye: Conjunctiva irritation TOLED5 135,S30,2002
oral
mouse lowest published toxic dose: 40 mL/kg/2 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Luekopenia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,170,1994
oral
mouse lowest published toxic dose: 40 mL/kg/2 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,170,1994
oral
rat lowest published toxic dose: 40 mL/kg/2 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Luekopenia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,170,1994
oral
rat lowest published toxic dose: 40 mL/kg/2 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,170,1994
skin
rabbit lowest published toxic dose: 455 mL/kg/13 week- intermittent Behavioral: General anesthetic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHBC 9,509,1954
skin
rabbit lowest published toxic dose: 900 mL/kg/90 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,170,1994

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm;short term exposure limit 150 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 150 ppm DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
FAATDF 13,747,1989
TOXICOLOGY REVIEW
CRTXB2 30,307,2000
TOXICOLOGY REVIEW
TOLED5 140-141,249,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (360 mg/m³) DTLWS* 3,27,1973
Occupational Exposure Limit - AUSTRIA MAK 100 ppm (375 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm (369 mg/m³), short term exposure limit 150 ppm (553 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (185 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (360 mg/m³), short term exposure limit 150 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (360 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY MAK 100 ppm (375 mg/m³), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 50 ppm (180 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 375 mg/m³, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (360 mg/m³), KZG- week 200 ppm (720 mg/m³), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (375 mg/m³), short term exposure limit 300 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 150 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 150 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 100 ppm;
short term exposure limit 150 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81815;
Number of Industries 44;
Total Number of Facilities 5,953;
Number of Occupations 36;
Total Number of Employees Exposed 26,413
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81815;
Number of Industries 204;
Total Number of Facilities 25,947;
Number of Occupations 133;
Total Number of Employees Exposed 373,990;
Total Number of Female Employees Exposed 110,572

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent for coatings, cellulose, acrylics dyes, inks, and stains
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #99

REFERENCES:
CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solvent for coatings, cellulose, acrylics dyes, inks, and stains

NIOSH PROFILE (GLYCOL ETHERS), SRI, 2/77

NIOSH PROFILE (GLYCOL ETHERS), SRC, 3/82

RTECS Compound Description:
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

SYNONYMS:
1 - Methoxy - 2 - propanol Dowanol 33B Dowanol PM Dowanol PM glycol ether Dowtherm 209 Glycol ether PM Methoxy ether of propylene glycol Methyl proxitol PGME	Poly - Solve MPM Propasol solvent M Propylene glycol methyl ether Propylene glycol monomethyl ether Propylene glycol monomethyl ether (ACGIH) Propylenglykol - monomethylaether (German) Ucar Solvent LM (Obs.) alpha - Propylene glycol monomethyl ether

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
eye rabbit	500 mg/24 hour	mild	85JCAE -,625,1986
skin rabbit	500 mg open irritation test	mild	UCDS** 11/15/1971

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 3,000 ppm/6 hour (6-15 day pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	FAATDF 4,784,1984
inhalation rat	lowest published toxic concentration: 3,000 ppm/6 hour (multigeneration)	Reproductive: Other effects on female Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Physical	TOSCF2 50,249,1999
oral mouse	lowest published toxic dose: 3.3 gm/kg (multigenerations)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB86170578
oral mouse	lowest published toxic dose: 3.3 gm/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Hepatobiliary system	NTIS** #PB86170578
oral mouse	lowest published toxic dose: 3.3 gm/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB86170578
oral mouse	lowest published toxic dose: 115.5 gm/kg (7 day male/7 day prior to copulation/21 day pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB86170578
oral rabbit	lowest published toxic dose: 936 mg/kg (7-19 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	TOSCF2 71,217,2003

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation guinea pig	lowest published lethal concentration: 15,000 ppm/7 hour	Behavioral: Sleep	AMIHBC 9,509,1954
inhalation human	lowest published toxic concentration: 3,000 ppm	Olfaction: Tumors Behavioral: General anesthetic Gastrointestinal: Nausea or vomiting	NPIRI* 1,105,1974
inhalation human	lowest published toxic concentration: 2,580 mg/m³	Eye: Lacrimation	VCVGK* -,169,1984
inhalation human	lowest published toxic concentration: 7,540 mg/m³	Eye: Conjunctiva irritation	VCVGK* -,169,1984
inhalation human	lowest published toxic concentration: 830 mg/m³/1 hour	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVGK* -,170,1984
inhalation mouse	lowest published toxic concentration: 1,000 ppm	Liver: Other changes	TOXID9 72,178,2003
inhalation mouse	lowest published toxic concentration: 3,000 ppm	Behavioral: Antianxiety	TOXID9 72,178,2003
inhalation rat	lethal concentration (50 percent kill): 10,000 ppm/5 hour	N/R	NPIRI* 1,105,1974
inhalation rat	lowest published toxic concentration: 18,400 mg/m³	Behavioral: Alteration of classical conditioning	VCVGK* -,169,1984
inhalation rat	lowest published toxic concentration: 1,000 ppm	Liver: Other changes	TOXID9 72,178,2003
inhalation rat	lowest published toxic concentration: 1,000 ppm	Kidney, Ureter, and Bladder: Other changes	TOXID9 72,178,2003
inhalation rat	lowest published toxic concentration: 3,000 ppm	Behavioral: Antianxiety	TOXID9 72,178,2003
inhalation rabbit	lowest published lethal concentration: 15,000 ppm/7 hour	N/R	AMIHBC 9,509,1954
intraperitoneal mouse	lethal dose : >500 mg/kg	N/R	CBCCT* 4,110,1952
intraperitoneal rat	lethal dose (50 percent kill): 3,720 mg/kg	N/R	38MKAJ 2C,3977,1982
intravenous dog	lethal dose (50 percent kill): 2 gm/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	ARZNAD 22,569,1972
intravenous mouse	lethal dose (50 percent kill): 5,300 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	ARZNAD 22,569,1972
intravenous rat	lethal dose (50 percent kill): 4,200 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	ARZNAD 22,569,1972
intravenous rabbit	lethal dose (50 percent kill): 1,200 mg/kg	N/R	ARZNAD 22,569,1972
oral dog	lethal dose (50 percent kill): 5 gm/kg	N/R	ARZNAD 22,569,1972
oral mouse	lethal dose (50 percent kill): 11,700 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	ARZNAD 22,569,1972
oral rat	lowest published lethal dose: 3,739 mg/kg	Eye: Chromodacryorrhea Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia	NTIS** OTS0520402
oral rat	lethal dose (50 percent kill): 6,600 mg/kg	Brain and Coverings: Other degenerative changes Behavioral: General anesthetic Lung, Thorax, or Respiration: Dyspnea	VCVGK* -,169,1984
oral rabbit	lethal dose (50 percent kill): 5,700 mg/kg	N/R	ARZNAD 22,569,1972
subcutaneous rat	lethal dose (50 percent kill): 7,800 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	ARZNAD 22,569,1972
subcutaneous rabbit	lethal dose (50 percent kill): 5 gm/kg	N/R	ARZNAD 22,569,1972
skin rabbit	lethal dose (50 percent kill): 13 gm/kg	N/R	NPIRI* 1,105,1974

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation guinea pig	lowest published toxic concentration: 6,000 ppm/7 hour/16 week- intermittent	Behavioral: General anesthetic Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AMIHBC 9,509,1954
inhalation monkey	lowest published toxic concentration: 10,000 ppm/4 hour/13 week- intermittent	Liver: Other changes Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AMIHBC 9,509,1954
inhalation mouse	lowest published toxic concentration: 3,000 ppm/6 hour/11 day- intermittent	Liver: Changes in liver weight	TXAPA9 61,368,1981
inhalation rat	lowest published toxic concentration: 3,000 ppm/6 hour/11 day- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes in urine composition	TXAPA9 61,368,1981
inhalation rat	lowest published toxic concentration: 3,000 ppm/6 hour/13 week- intermittent	Liver: Changes in liver weight	FAATDF 3,627,1983
inhalation rat	lowest published toxic concentration: 11,000 mg/m³/6 hour/9 day- intermittent	Brain and Coverings: Other degenerative changes Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes in urine composition	VCVGK* -,170,1994
inhalation rat	lowest published toxic concentration: 2,200 mg/m³/12 day- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	VCVGK* -,170,1994
inhalation rabbit	lowest published toxic concentration: 3,000 ppm/6 hour/13 week- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	FAATDF 3,627,1983
multiple human	lowest published toxic dose: 100 ppm/3 hour/2 week- intermittent	Olfaction: Other olfaction effects	TOLED5 135,S30,2002
multiple human	lowest published toxic dose: 150 ppm/3 hour/2 week- intermittent	Olfaction: Other olfaction effects Eye: Conjunctiva irritation	TOLED5 135,S30,2002
oral mouse	lowest published toxic dose: 40 mL/kg/2 week- intermittent	Liver: Hepatitis (hepatocellular necrosis), diffuse Blood: Luekopenia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,170,1994
oral mouse	lowest published toxic dose: 40 mL/kg/2 week- intermittent	Liver: Hepatitis (hepatocellular necrosis), diffuse Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,170,1994
oral rat	lowest published toxic dose: 40 mL/kg/2 week- intermittent	Liver: Hepatitis (hepatocellular necrosis), diffuse Blood: Luekopenia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,170,1994
oral rat	lowest published toxic dose: 40 mL/kg/2 week- intermittent	Liver: Hepatitis (hepatocellular necrosis), diffuse Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,170,1994
skin rabbit	lowest published toxic dose: 455 mL/kg/13 week- intermittent	Behavioral: General anesthetic Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHBC 9,509,1954
skin rabbit	lowest published toxic dose: 900 mL/kg/90 day- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,170,1994

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 100 ppm	DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 100 ppm;short term exposure limit 150 ppm	DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	short term exposure limit 150 ppm	DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW		FAATDF 13,747,1989
TOXICOLOGY REVIEW		CRTXB2 30,307,2000
TOXICOLOGY REVIEW		TOLED5 140-141,249,2003

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air	time-weighted average 100 ppm (360 mg/m³)	DTLWS* 3,27,1973
Occupational Exposure Limit - AUSTRIA	MAK 100 ppm (375 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM	time-weighted average 100 ppm (369 mg/m³), short term exposure limit 150 ppm (553 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK	time-weighted average 50 ppm (185 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND	time-weighted average 100 ppm (360 mg/m³), short term exposure limit 150 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE	VME 100 ppm (360 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY	MAK 100 ppm (375 mg/m³), JAN1999
Occupational Exposure Limit - NORWAY	time-weighted average 50 ppm (180 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS	MAC-TGG 375 mg/m³, 2003
Occupational Exposure Limit - SWITZERLAND	MAK- week 100 ppm (360 mg/m³), KZG- week 200 ppm (720 mg/m³), JAN1999
Occupational Exposure Limit - UNITED KINGDOM	time-weighted average 100 ppm (375 mg/m³), short term exposure limit 300 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; short term exposure limit 150 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 150 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air	10 hour time-weighted average 100 ppm; short term exposure limit 150 ppm	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 81815; Number of Industries 44; Total Number of Facilities 5,953; Number of Occupations 36; Total Number of Employees Exposed 26,413
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 81815; Number of Industries 204; Total Number of Facilities 25,947; Number of Occupations 133; Total Number of Employees Exposed 373,990; Total Number of Female Employees Exposed 110,572

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent for coatings, cellulose, acrylics dyes, inks, and stains
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #99

REFERENCES:
CODEN	REFERENCE
38MKAJ	"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE	"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC	AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ARZNAD	Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CBCCT*	"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
CRTXB2	CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS*	"Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FAATDF	Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
NIOSH*	National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI*	Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5	Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2	Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9	Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS**	Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.