The Registry of Toxic Effects of Chemical Substances

2 - Propanol, 1,1',1'' - nitrilotri -

RTECS #: UB8750000

CAS #: 122-20-3

UPDATE: October 1997 MW: 191.31 MF: C9H21NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1,1',1'' - Nitrilotri - 2 - propanol
  2. Triisopropanolamine
  1. Tris (2 - hydroxypropyl) amine
  2. Tris (2 - hydroxy - 1 - propyl) amine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 mg severe AJOPAA 29,1363,1946


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lethal dose (50 percent kill): 1,580 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes 		JIHTAB 23,259,1941
oral
mouse 		lethal dose (50 percent kill): 2,520 mg/kg Behavioral: Muscle contraction or spasticity GISAAA 45(3),79,1980
oral
rat 		lethal dose (50 percent kill): 4,730 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Body temperature decrease 		GTPZAB 30(7),46,1986
oral
rabbit 		lethal dose (50 percent kill): 11 gm/kg Behavioral: Muscle contraction or spasticity GISAAA 45(3),79,1980
skin
mammal (species unspecified) 		lethal dose (50 percent kill): >1 gm/kg N/R GTPZAB 30(7),46,1986
skin
rabbit 		lowest published lethal dose: 10 mL/kg N/R UCDS** 4/21/1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 28 gm/kg/2 week- continuous Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Changes in bladder weight 		JACTDZ 6(1),53,1987


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0259;
Number of Industries 27;
Total Number of Facilities 1,842;
Number of Occupations 44;
Total Number of Employees Exposed 23,845
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0259;
Number of Industries 51;
Total Number of Facilities 2,702;
Number of Occupations 58;
Total Number of Employees Exposed 64,304;
Total Number of Female Employees Exposed 8,631


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

NIOSH PROFILE (ALKANOLAMINES), SRC, 5/81

RTECS Compound Description:
   Primary Irritant

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