The Registry of Toxic Effects of Chemical Substances

2 - Propenenitrile, 2 - methyl -

RTECS #: UD1400000

CAS #: 126-98-7

UPDATE: November 2004 MW: 67.10 MF: C4H5N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Cyanopropene - 1
  2. Isopropene cyanide
  3. Isopropenylnitrile
  4. Methacrylonitrile
  5. Methylacrylonitrile
  1. alpha - Methylacrylonitrile
  2. Methylacrylonitrile (ACGIH)
  3. 2 - Methylpropenenitrile
  4. RCRA waste number U152
  5. USAF ST - 40


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 mg N/R JIHTAB 31,113,1949
eye
rabbit 		500 mg/24 hour mild 85JCAE -,901,1986
skin
rabbit 		200 mg mild JIHTAB 31,113,1949
skin
rabbit 		500 mg/24 hour mild 85JCAE -,901,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 20,365,1993
oral
rat 		lowest published toxic dose: 350 mg/kg (1-7 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		BECTA6 48,696,1992
oral
rat 		lowest published toxic dose: 150 mg/kg (10 day pregnant) Reproductive: Other effects to embryo or fetus TXAPA9 163,149,2000
oral
rat 		lowest published toxic dose: 20 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB97-176390
oral
rat 		lowest published toxic dose: 20 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Behavioral 		NTIS** #PB97-176390


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published lethal concentration: 52 ppm/7 hour Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea 		AIHAAP 29,202,1968
inhalation
guinea pig 		lethal concentration (50 percent kill): 88 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold AIHAAP 29,202,1968
inhalation
mouse 		lethal concentration (50 percent kill): 36 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold AIHAAP 29,202,1968
inhalation
rat 		lethal concentration (50 percent kill): 328 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		AIHAAP 29,202,1968
inhalation
rabbit 		lethal concentration (50 percent kill): 37 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold AIHAAP 29,202,1968
intraperitoneal
mouse 		lowest published lethal dose: 15 mg/kg N/R JIHTAB 31,113,1949
oral
mouse 		lethal dose (50 percent kill): 17 mg/kg N/R JUZIAG 94,664,1985
oral
mouse 		lowest published toxic dose: 3.15 mg/kg Blood: Other changes TOXID9 72,319,2003
oral
rat 		lethal dose (50 percent kill): 120 mg/kg N/R GTPZAB 29(5),37,1985
oral
rat 		lowest published toxic dose: 60 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		JJTHEC 65,523,2002
oral
rabbit 		lethal dose (50 percent kill): 16 mg/kg N/R GTPZAB 29(5),37,1985
skin
rat 		lethal dose (50 percent kill): 2,080 mg/kg N/R GTPZAB 29(5),37,1985
skin
rabbit 		lethal dose (50 percent kill): 12,500 µg/kg N/R NTIS** OTS0534646


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 109 ppm/7 hour/91 day- intermittent Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIHAAP 29,202,1968
intramuscular
rat 		lowest published toxic dose: 2,940 mg/kg/21 week- intermittent Liver: Changes in liver weight NTIS** #PB97-176390
intramuscular
rat 		lowest published toxic dose: 294 mg/kg/21 week- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct NTIS** #PB97-176390
oral
rat 		lowest published toxic dose: 5,400 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** PB97-176390
oral
rat 		lowest published toxic dose: 420 mg/kg/7 day- intermittent Liver: Other changes

Liver: Changes in liver weight 		JJTHEC 65,523,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (3 mg/m3) (skin) DTLWS* 3,22,1973
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (3 mg/m3), Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (2.7 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (3 mg/m3), short term exposure limit 3 ppm (9 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (3 mg/m3), Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3 mg/m3, Skin, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLACRYLONITRILE-air 10 hour time-weighted average 1 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5279;
Number of Industries 3;
Total Number of Facilities 58;
Number of Occupations 2;
Total Number of Employees Exposed 213


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat
NTP Toxicity studies, RPT# TOX-47, October 2000
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJTHEC Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
JUZIAG Juzen Igakkai Zasshi. Journal of Juzen Medical Society. (Kanazawa Daigaku Juzen Igakkai, 13-1 Takara-machi, Kanazawa 920, Japan) V.1- 1896-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Primary Irritant

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