The Registry of Toxic Effects of Chemical Substances

1 - Propene, 2 - methyl -

RTECS #: UD0890000

CAS #: 115-11-7

UPDATE: February 2005 MW: 56.12 MF: C4H8


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1 - Dimethylethene
  2. 1,1 - Dimethylethylene
  3. gamma - Butylene
  4. Isobutene
  1. Isopropylidenemethylene
  2. 2 - Methylpropene
  3. 2 - Methylpropylene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 252,000 mg/kg/105 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors 		NTIS** PB99-147670


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 314,000 mg/m3/2 hour N/R VCVGH* -,54,1990
inhalation
mouse 		lethal concentration (16 percent kill): 250,000 mg/m3/2 hour N/R VCVGH* -,54,1990
inhalation
mouse 		lethal concentration (84 percent kill): 680,000 mg/m3/2 hour N/R VCVGH* -,54,1990
inhalation
rat 		lethal concentration (50 percent kill): 550,000 mg/m3/4 hour N/R VCVGH* -,54,1990
inhalation
rat 		lethal concentration (16 percent kill): 514,000 mg/m3/4 hour N/R VCVGH* -,54,1990
inhalation
rat 		lethal concentration (84 percent kill): 720,000 mg/m3/4 hour N/R VCVGH* -,54,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81854;
Number of Industries 13;
Total Number of Facilities 432;
Number of Occupations 22;
Total Number of Employees Exposed 5,502
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81854;
Number of Industries 17;
Total Number of Facilities 942;
Number of Occupations 16;
Total Number of Employees Exposed 7,002;
Total Number of Female Employees Exposed 982


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to make intermediates
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat
NCI Carcinogenesis Studies (inhal);no evidence:mouse


REFERENCES:

CODEN
REFERENCE
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used to make intermediates

Top 50 chemical production: 1.29 billions lbs in 1992, 0.97 billions in 1991

RTECS Compound Description:
   Tumorigen

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