The Registry of Toxic Effects of Chemical Substances
Propionaldehyde, 3 - (methylthio) - RTECS #: UE2285000
CAS #: 3268-49-3
The Registry of Toxic Effects of Chemical Substances
Propionaldehyde, 3 - (methylthio) - |
| UPDATE: February 2004 | MW: 104.18 | MF: C4H8OS |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
0.1 mL
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moderate
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VHTODE 42,77,2000
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skin | rabbit
500 µL/24 hour
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severe
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NTIS** OTS0546239
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skin | rabbit
0.5 mL/4 hour
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moderate
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VHTODE 42,77,2000
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
|
micronucleus test
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inhalation | mouse
37.4 ppm/1 hour/2 day
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VHTODE 42,77,2000
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | mouse
lethal concentration (50 percent kill): 5,400 mg/m3/2 hour
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N/R
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GISAAA 49(1),85,1984
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inhalation | mouse
lethal concentration (50 percent kill): 5,400 mg/m3/2 hour
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Brain and Coverings: Other degenerative changes | Liver: Liver function tests impaired
VCVGK* -,372,1984
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inhalation | rat
lethal concentration (50 percent kill): 5,820 mg/m3/4 hour
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N/R
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GISAAA 49(1),85,1984
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inhalation | rat
lethal concentration (50 percent kill): 5,820 mg/m3/4 hour
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Brain and Coverings: Other degenerative changes | Liver: Liver function tests impaired
VCVGK* -,372,1984
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inhalation | rat
lowest published toxic concentration: 246.2 ppm
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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VHTODE 42,330,2000
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oral | mouse
lethal dose (50 percent kill): 1,620 mg/kg
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N/R
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GISAAA 49(1),85,1984
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oral | mouse
lethal dose (50 percent kill): 1,620 mg/kg
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Brain and Coverings: Other degenerative changes | Liver: Liver function tests impaired
VCVGK* -,372,1984
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oral | rat
lethal dose (50 percent kill): 700 mg/kg
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Behavioral: Somnolence (general depressed activity) | Behavioral: Muscle weakness Gastrointestinal: Alteration in gastric secretion
NTIS** OTS0546239
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oral | rat
lethal dose (50 percent kill): 4,400 mg/kg
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Brain and Coverings: Other degenerative changes | Liver: Liver function tests impaired
VCVGK* -,372,1984
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oral | rat
lethal dose (50 percent kill): 1.52 mg/kg
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Eye: Lacrimation | Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes
VHTODE 42,77,2000
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skin | rabbit
lowest published lethal dose: 2,500 mg/kg
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Behavioral: Somnolence (general depressed activity) | Behavioral: Excitement Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0534366
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skin | rabbit
lethal dose (50 percent kill): 747 µg/kg/24 hour
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Eye: Lacrimation | Behavioral: Rigidity (includes catalepsy) Lung, Thorax, or Respiration: Other changes
VHTODE 42,77,2000
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lowest published toxic concentration: 246.2 ppm/9 day- continuous
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Lung, Thorax, or Respiration: Other changes | Liver: Changes in liver weight
VHTODE 42,330,2000
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inhalation | rat
lowest published toxic concentration: 96.8 ppm/2 day- continuous
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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VHTODE 42,330,2000
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inhalation | rat
lowest published toxic concentration: 23.6 ppm/9 day- continuous
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Blood: Changes in leukocyte (WBC) count
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VHTODE 42,330,2000
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inhalation | rat
lowest published toxic concentration: 23.6 ppm/9 day- continuous
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Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
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VHTODE 42,330,2000
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inhalation | rat
lowest published toxic concentration: 246.2 ppm/9 day- continuous
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Endocrine: Changes in spleen weight | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
VHTODE 42,330,2000
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inhalation | rat
lowest published toxic concentration: 246.2 ppm/9 day- continuous
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Blood: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VHTODE 42,330,2000
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inhalation | rat
lowest published toxic concentration: 96.8 ppm/9 day- continuous
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Endocrine: Changes in spleen weight | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
VHTODE 42,330,2000
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 83834; |
Number of Industries 1; Total Number of Facilities 21; Number of Occupations 3; Total Number of Employees Exposed 207 | |||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
GISAAA
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Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1936-
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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VCVGK*
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"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia".
(Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia,
1994.
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VHTODE
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Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology,
Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
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