The Registry of Toxic Effects of Chemical Substances

Propionaldehyde

RTECS #: UE0350000

CAS #: 123-38-6

UPDATE: November 2003 MW: 58.09 MF: C3H6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Aldehyde propionique (French)
  2. Methylacetaldehyde
  3. NCI - C61029
  4. Propaldehyde
  1. Propanal
  2. Propionic aldehyde
  3. Propyl aldehyde
  4. Propylic aldehyde


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		41 mg severe UCDS** 4/25/1958
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,268,1986
skin
rabbit 		500 mg open irritation test mild UCDS** 4/25/1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage mammal (species unspecified) lymphocyte 100 mmol/L MUREAV 283,131,1992
unscheduled DNA synthesis rat liver 30 µmol/L MUREAV 323,121,1994
mutation in mammalian somatic cells hamster lung 10 mmol/L MUTAEX 4,277,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 21,800 mg/m3 N/R GTPZAB 12(7),16,1968
inhalation
mouse 		lethal concentration (50 percent kill): 21,800 mg/m3/2 hour N/R 85GMAT -,102,1982
inhalation
mouse 		lethal concentration (50 percent kill): 21,800 mg/m3/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,370,1984
inhalation
mouse 		lowest published toxic concentration: 10,000 mg/m3 Eye: Conjunctiva irritation

Behavioral: General anesthetic

Lung, Thorax, or Respiration: Dyspnea 		VCVGK* -,370,1984
inhalation
rat 		lowest published lethal concentration: 8,000 ppm/4 hour N/R AMIHBC 4,119,1951
inhalation
rat 		lowest published toxic concentration: 600 mg/m3/10 minute Eye: Conjunctiva irritation

Behavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,370,1984
inhalation
rat 		lowest published toxic concentration: 4 mg/m3/4 hour Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		VCVGK* -,371,1984
intraperitoneal
mouse 		lethal dose (50 percent kill): 200 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression 		NTIS** OTS0533450
intraperitoneal
rat 		lethal dose (50 percent kill): 200 mg/kg Behavioral: General anesthetic

Behavioral: Muscle weakness 		NTIS** OTS0533450
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 1,400 mg/kg N/R GTPZAB 32(10),25,1988
oral
mouse 		lowest published lethal dose: 800 mg/kg N/R KODAK* 21MAY1971
oral
rat 		lethal dose (50 percent kill): 1,410 mg/kg N/R AMIHBC 4,119,1951
oral
rat 		lethal dose (50 percent kill): 1,410 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,370,1984
subcutaneous
mouse 		lethal dose (50 percent kill): 680 mg/kg Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold 		APTOA6 6,299,1950
subcutaneous
rat 		lethal dose (50 percent kill): 820 mg/kg Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold 		APTOA6 6,299,1950
skin
guinea pig 		lethal dose (50 percent kill): 10 mL/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0533450
skin
rabbit 		lethal dose (50 percent kill): 2,460 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		NTIS** OTS0543436
unreported route
mouse 		lethal dose (50 percent kill): 800 mg/kg N/R HBPTO* 1,825,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 4 mg/m3/24 hour/75 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 47(4),10,1982
inhalation
rat 		lowest published toxic concentration: 23 mg/m3/3 week- intermittent Lung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,371,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84709;
Number of Industries 2;
Total Number of Facilities 80;
Number of Occupations 4;
Total Number of Employees Exposed 1,543
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84709;
Number of Industries 2;
Total Number of Facilities 25;
Number of Occupations 16;
Total Number of Employees Exposed 2,086;
Total Number of Female Employees Exposed 187


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to make PROPIONIC ACID, alkyl resins and plasticizers
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used to make PROPIONIC ACID, alkyl resins and plasticizers

NIOSH PROFILE (ALDEHYDES), SRC, 4/78

NIOSH PROFILE (ALDEHYDES), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Primary Irritant

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