The Registry of Toxic Effects of Chemical Substances

Propionic acid, 2 - (2,4 - dichlorophenoxy) -

RTECS #: UF1050000

CAS #: 120-36-5

UPDATE: August 2003 MW: 235.07 MF: C9H8Cl2O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Acide 2 - (2,4 - dichloro - phenoxy) propionique (French)
  2. Acido 2 - (2,4 - dicloro - fenossi) - propionico (Italian)
  3. BH 2,4 - DP
  4. Cornox RK
  5. Cornoxynil
  6. 2 - (2,4 - Dichloor - fenoxy) - propionzuur (Dutch)
  7. alpha - (2,4 - Dichlorophenoxy) propionic acid
  8. 2 - (2,4 - Dichlorophenoxy) propionic acid
  9. Dichloroprop
  10. 2 - (2,4 - Dichlor - phenoxy) - propionsaeure (German)
  11. Propanoic acid, 2 - (2,4 - dichlorophenoxy) -
  12. Dichlorprop
  1. 2,4 - DP
  2. Hedonal DP
  3. Herbizid DP
  4. Kildip
  5. Kwas 2,4 - dwuchlorofenoksypropionowy (Polish)
  6. Kyselina 2 - (2,4 - dichlorfenoxy) propionova (Czech)
  7. Mayclene
  8. Seritox 50
  9. U46 DP - Fluid
  10. Weedone 170
  11. Canapur DP


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Saccharomyes cerevisiae 700 mg/L (-enzymatic activation step) ZAPOAK 9,483,1969


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 5 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		ARZNAD 33,1479,1983
oral
mouse 		lowest published toxic dose: 3 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ARZNAD 33,1479,1983
oral
mouse 		lowest published toxic dose: 4 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system ARZNAD 33,1479,1983
oral
mouse 		lowest published toxic dose: 20 mg/kg (4-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TJADAB 33,11A,1986
oral
rat 		lowest published toxic dose: 20 mg/kg (4-18 day pregnant) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical 		TJADAB 33,11A,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >1,600 mg/m3 Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity 		GTPZAB 27(9),50,1983
oral
guinea pig 		lethal dose (50 percent kill): 620 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Behavioral: Coma 		GISAAA 50(9),22,1985
oral
mouse 		lethal dose (50 percent kill): 309 mg/kg N/R RPZHAW 31,373,1980
oral
rat 		lethal dose (50 percent kill): 344 mg/kg N/R ATDAEI 1,177,1992
subcutaneous
mouse 		lethal dose (50 percent kill): 1,400 mg/kg N/R 85JCAE -,547,1986
skin
mouse 		lethal dose (50 percent kill): 1,400 mg/kg N/R 28ZEAL 5,76,1976
skin
rat 		lethal dose (50 percent kill): 1,880 mg/kg Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Body temperature decrease 		GISAAA 50(9),22,1985


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 100 mg/m3/17 week- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		GTPZAB 27(9),50,1983
oral
rat 		lowest published toxic dose: 6,188 mg/kg/17 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field GISAAA 50(9),22,1985
oral
rat 		lowest published toxic dose: 1,893 mg/kg/1 year- intermittent Liver: Changes in liver weight

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Changes in: Na 		GISAAA 50(9),22,1985
skin
rabbit 		lowest published toxic dose: 4,500 mg/kg/30 day- intermittent Skin: After systemic exposure: Dermatitis, other

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GISAAA 50(9),22,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 41,357,1986
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,156,1987
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
JTCTDW 38,111,2000


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Unsupported RBREV* -,74,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate, solvent, fumigant, scouring compound and metal decreasing agent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960-

Used as intermediate, solvent, fumigant, scouring compound and metal decreasing agent

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

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