The Registry of Toxic Effects of Chemical Substances

Propionitrile, 2,2' - azobis (2 - methyl -

RTECS #: UG0800000

CAS #: 78-67-1

UPDATE: October 1997 MW: 164.24 MF: C8H12N4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Aceto AZIB
  2. AIBN
  3. Azobisisobutylonitrile
  4. alpha,alpha' - Azobisisobutylonitrile
  5. Azobisisobutyronitrile
  6. 2,2' - Azobis (isobutyronitrile)
  7. 2,2' - Azobis (2 - methylpropionitrile)
  1. alpha,alpha' - Azodiisobutyronitrile
  2. 2,2' - Azodiisobutyronitrile
  3. 2,2' - Dicyano - 2,2' - azopropane
  4. Poly - Zole AZDN
  5. Porofor 57
  6. Porophor N
  7. VAZO 64


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >12 gm/m3/4 hour Eye: Conjunctiva irritation

Behavioral: Excitement

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555369
intraperitoneal
mouse 		lethal dose (50 percent kill): 25 mg/kg N/R NTIS** AD691-490
intraperitoneal
rat 		lethal dose (50 percent kill): 25 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		NTIS** OTS0555369
oral
mouse 		lethal dose (50 percent kill): 700 mg/kg N/R 85KYAH 11,146,1989
oral
rat 		lethal dose (50 percent kill): 100 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		NTIS** OTS0555369
subcutaneous
guinea pig 		lowest published lethal dose: 50 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		ATXKA8 16,367,1957
subcutaneous
mouse 		lowest published lethal dose: 40 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		ATXKA8 16,367,1957
subcutaneous
rat 		lowest published lethal dose: 30 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		ATXKA8 16,367,1957
subcutaneous
rabbit 		lowest published lethal dose: 50 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		ATXKA8 16,367,1957


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 2,200 mg/kg/11 day- continuous Gastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0555369


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84048;
Number of Industries 4;
Total Number of Facilities 63;
Number of Occupations 7;
Total Number of Employees Exposed 640
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84048;
Number of Industries 7;
Total Number of Facilities 89;
Number of Occupations 21;
Total Number of Employees Exposed 4,313;
Total Number of Female Employees Exposed 116


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as polymerization initiator, free radical generator
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8909
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as polymerization initiator, free radical generator

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