The Registry of Toxic Effects of Chemical Substances

Propyl alcohol

RTECS #: UH8225000

CAS #: 71-23-8

UPDATE: February 2005 MW: 60.11 MF: C3H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1 - Hydroxypropane
  2. 1 - Propanol
  3. 1 - Propyl alcohol
  4. Alcool propilico (Italian)
  5. Alcool propylique (French)
  6. Ethyl carbinol
  7. Optal
  8. Osmosol Extra
  9. Propan - 1 - ol
  10. Propanol
  1. Propanol - 1
  2. Propanole (German)
  3. Propanolen (Dutch)
  4. Propanoli (Italian)
  5. Propylic alcohol
  6. Propylowy alkohol (Polish)
  7. n - Propanol
  8. n - Propyl alcohol
  9. n - Propyl alcohol (ACGIH:OSHA)
  10. n - Propyl alkohol (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,191,1986
skin
human 		1,00%/47 hour mild CODEDG 39,240,1998
skin
human 		1,00%/24 hour mild CODEDG 68,192,1988
skin
rabbit 		500 mg open irritation test mild UCDS** 6/28/1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 4 pph (-enzymatic activation step) ABMGAJ 23,843,1969
sex chromosome loss and nondisjunction Aspergillus nidulans 18,000 ppm MUREAV 215,187,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 7,000 ppm/7 hour (6 week male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) NTOTDY 7,779,1985
inhalation
rat 		lowest published toxic concentration: 7,000 ppm/7 hour (1-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FCTOD7 26,247,1988
inhalation
rat 		lowest published toxic concentration: 10,000 ppm/7 hour (1-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FCTOD7 26,247,1988


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 50 gm/kg/81 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia 		ARGEAR 45,19,1975
subcutaneous
rat 		lowest published toxic dose: 6 gm/kg/95 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia 		ARGEAR 45,19,1975


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 48 gm/m3 N/R GTPZAB 18(3),48,1974
inhalation
mouse 		lethal concentration (50 percent kill): 48,000 mg/m3 Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes 		VCVGK* -,96,1984
inhalation
rat 		lowest published lethal concentration: 4,000 ppm/4 hour N/R AMIHBC 10,61,1954
inhalation
rat 		lowest published lethal concentration: 9,800 mg/m3/4 hour Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes 		VCVGK* -,96,1984
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 1,208 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
hamster 		lethal dose (50 percent kill): 2,338 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
mouse 		lethal dose (50 percent kill): 3,125 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
rat 		lethal dose (50 percent kill): 2,164 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
rabbit 		lethal dose (50 percent kill): 515 mg/kg N/R EVHPAZ 61,321,1985
intravenous
cat 		lowest published lethal dose: 4,008 mg/kg N/R JPETAB 16,1,1920
intravenous
mouse 		lethal dose (50 percent kill): 697 mg/kg N/R EVHPAZ 61,321,1985
intravenous
rat 		lethal dose (50 percent kill): 590 mg/kg N/R EVHPAZ 61,321,1985
intravenous
rabbit 		lethal dose (50 percent kill): 483 mg/kg N/R EVHPAZ 61,321,1985
oral
dog 		lowest published lethal dose: 3 gm/kg Gastrointestinal: Other changes

Blood: Hemorrhage 		COREAF 81,192,1875
oral
mouse 		lethal dose (50 percent kill): 6,800 mg/kg N/R PSDTAP 9,276,1968
oral
mouse 		lowest published lethal dose: 140 mg/kg Behavioral: General anesthetic VCVGK* -,96,1984
oral
rat 		lethal dose (50 percent kill): 1,870 mg/kg N/R AMIHBC 10,61,1954
oral
rat 		lethal dose (50 percent kill): 2,200 mg/kg Behavioral: General anesthetic VCVGK* -,96,1984
oral
rabbit 		lethal dose (50 percent kill): 2,825 mg/kg N/R IMSUAI 41,31,1972
oral
rabbit 		lowest published lethal dose: 3,500 mg/kg Behavioral: General anesthetic VCVGK* -,96,1984
oral
woman 		lowest published lethal dose: 5,700 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes 		ATXKA8 16,84,1956
subcutaneous
dog 		lowest published lethal dose: 4 gm/kg Gastrointestinal: Other changes

Blood: Hemorrhage 		COREAF 81,192,1875
subcutaneous
mammal (species unspecified) 		lowest published lethal dose: 5 gm/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes 		ATXKA8 16,84,1956
subcutaneous
mouse 		lethal dose (50 percent kill): 4,700 mg/kg N/R TXAPA9 18,185,1971
subcutaneous
rabbit 		lowest published lethal dose: 3 gm/kg N/R BDBU** -,-,1930
skin
rabbit 		lethal dose (50 percent kill): 5,040 mg/kg N/R AMIHBC 10,61,1954
unreported route
rabbit 		lowest published lethal dose: 4,500 mg/kg N/R THMOAM 6,327,1892


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/24 hour/90 day- continuous Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Liver: Multiple effects 		VCVGK* -,98,1994
oral
rat 		lowest published toxic dose: 16,800 mg/kg/28 day- continuous Endocrine: Changes in adrenal weight BIOFX* 15-4/1970
oral
rat 		lowest published toxic dose: 7 mL/kg/7 day- intermittent Liver: Other changes

Biochemical: Effect on specific coenzyme: B vitamins including folate 		JDGRAX 10(1-2),25,1978


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm (skin) DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm (skin);short term exposure limit 250 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 250 ppm (skin) DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
TOLED5 140-141,53,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,290,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (490 mg/m3) DTLVS* 3,217,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (500 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (500 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (500 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (500 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (500 mg/m3), short term exposure limit 250 ppm, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 200 ppm (500 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (492 mg/m3), short term exposure limit 250 ppm, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (500 mg.m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 200 ppm (500 mg/m3), short term exposure limit 250 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 200 ppm (500 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 100 mg/m3, short term exposure limit 200 mg/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 100 ppm (245 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 200 mg/m3, MAC(short term exposure limit) 600 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 150 ppm (350 mg/m3), KTV 250 ppm (600 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (500 mg/m3), Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 200 ppm (500 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (500 mg/m3), short term exposure limit 250 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 250 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 250 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYL ALCOHOL-air time-weighted average 200 ppm (Sk);
short term exposure limit 250 ppm (Sk) 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0256;
Number of Industries 151;
Total Number of Facilities 18,176;
Number of Occupations 103;
Total Number of Employees Exposed 122,603
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0256;
Number of Industries 130;
Total Number of Facilities 17,036;
Number of Occupations 99;
Total Number of Employees Exposed 226,129;
Total Number of Female Employees Exposed 84,196


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent, degreasing agent, antiseptic, and as a chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols II, 1401


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
BDBU** "Zur Pharmakologie Ungesattigter Alkohole, Dissertation," Bock, H., Pharmakologischen Institut der Universitat Breslau, Poland, 1930
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC.
PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
THMOAM Therapeutische Monatshefte. (Berlin, Germany) V.1-33, 1887-1919. For publisher information, see KLWOAZ.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solvent, degreasing agent, antiseptic, and as a chemical intermediate

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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