The Registry of Toxic Effects of Chemical Substances

Pyridine, 4 - methyl -

RTECS #: UT5425000

CAS #: 108-89-4

UPDATE: June 1998 MW: 93.14 MF: C6H7N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Ba 35846
  2. p - Methylpyridine
  3. 4 - Methylpyridine
  1. gamma - Picoline
  2. p - Picoline
  3. 4 - Picoline (8CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,841,1986
skin
rabbit 		480 mg open irritation test moderate UCDS** 2/21/1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 4 gm/m3 N/R GISAAA 57(9-10),64,1992
inhalation
rat 		lowest published lethal concentration: 1,000 ppm/4 hour N/R AMIHBC 10,61,1954
intraperitoneal
mouse 		lethal dose (50 percent kill): 335 mg/kg N/R TOXIA6 23,815,1985
intraperitoneal
rat 		lethal dose (50 percent kill): 163 mg/kg Behavioral: Somnolence (general depressed activity) FAATDF 5,920,1985
oral
wild bird 		lethal dose (50 percent kill): 422 mg/kg N/R AECTCV 12,355,1983
oral
mouse 		lethal dose (50 percent kill): 350 mg/kg N/R GISAAA 57(9-10),64,1992
oral
rat 		lethal dose (50 percent kill): 440 mg/kg N/R GISAAA 57(9-10),64,1992
skin
guinea pig 		lowest published lethal dose: 500 mg/kg N/R 85JCAE -,841,1986
skin
rabbit 		lethal dose (50 percent kill): 270 µL/kg N/R AMIHBC 10,61,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7969;
Number of Industries 3;
Total Number of Facilities 55;
Number of Occupations 7;
Total Number of Employees Exposed 9,556;
Total Number of Female Employees Exposed 1,119


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent for resins and in waterproofing agents for fabrics
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9273
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as a solvent for resins and in waterproofing agents for fabrics

RTECS Compound Description:
   Primary Irritant

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