The Registry of Toxic Effects of Chemical Substances

Pyrogallol

RTECS #: UX2800000

CAS #: 87-66-1

UPDATE: August 2004 MW: 126.12 MF: C6H6O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. C.I. 76515
  2. C.I. Oxidation Base 32
  3. Benzene, 1,2,3 - trihydroxy -
  4. 1,2,3 - Benzenetriol
  5. Fouramine Brown AP
  1. Fourrine PG
  2. Fourrine 85
  3. Pyrogallic acid
  4. 1,2,3 - Trihydroxybenzen (Czech)
  5. 1,2,3 - Trihydroxybenzene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,235,1986
skin
mouse 		0.1,25% TOXID9 72,52,2003
skin
rabbit 		2 mg/24 hour severe 85JCAE -,235,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 100 mg/L CALEDQ 14,251,1981
cytogenetic analysis hamster lung 60 µmol/L/2 hour MUREAV 540,29,2003
cytogenetic analysis intraperitoneal
mouse 		100 µmol/kg IJMRAQ 59,1442,1971
DNA adduct Escherichia coli 30 µmol/L MUREAV 89,95,1981
DNA repair Bacillus subtilis 50 mg/L ESKGA2 32,171,1986
mutation in microorganisms Escherichia coli 78 µg/plate (-enzymatic activation step) MUREAV 412,17,1998
mutation in microorganisms Salmonella typhimurium 1 µmol/plate (+/-enzymatic activation step) NEZAAQ 38,533,1983
micronucleus test hamster lung 50 µmol/L EVHPAZ 82,81,1989
micronucleus test intraperitoneal
mouse 		252 mg/kg MUREAV 90,91,1981
micronucleus test oral
mouse 		504 mg/kg MUREAV 90,91,1981
gene conversion and mitotic recombination Saccharomyes cerevisiae 300 mg/L MUREAV 135,109,1984
sister chromatid exchange hamster lung 25 µmol/L EVHPAZ 82,81,1989
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		125 mmol/L MUREAV 90,91,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 3 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		JACTDZ 2(4),325,1983
subcutaneous
rat 		lowest published toxic dose: 5 mg/kg (1 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes ENDOAO 57,466,1955


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 3,950 mg/kg/58 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		PAACA3 20,117,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 400 mg/kg N/R NTIS** AD691-490
intraperitoneal
mouse 		lethal dose (50 percent kill): 400 mg/kg Behavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia 		VCVGK* -,238,1994
intravenous
dog 		lowest published lethal dose: 80 mg/kg N/R HBTXAC 1,254,1955
intravenous
dog 		lowest published lethal dose: 80 mg/kg Behavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia 		VCVGK* -,238,1994
oral
wild bird 		lethal dose (50 percent kill): 75 mg/kg N/R AECTCV 12,355,1983
oral
dog 		lowest published lethal dose: 25 mg/kg N/R HBTXAC 1,254,1955
oral
dog 		lowest published lethal dose: 250 mg/kg Behavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia 		VCVGK* -,238,1994
oral
human 		lowest published lethal dose: 28 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes 		34ZIAG -,507,1969
oral
mouse 		lethal dose (50 percent kill): 300 mg/kg N/R GISAAA 38(8),6,1973
oral
mouse 		lethal dose (50 percent kill): 570 mg/kg Behavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia 		VCVGK* -,238,1994
oral
rat 		lethal dose (50 percent kill): 790 mg/kg Behavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia 		VCVGK* -,238,1994
oral
rabbit 		lethal dose (50 percent kill): 1,600 mg/kg Gastrointestinal: Gastritis

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion 		AJVRAH 23,1264,1962
oral
rabbit 		lethal dose (50 percent kill): 1,600 mg/kg Behavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia 		VCVGK* -,238,1994
subcutaneous
dog 		lowest published lethal dose: 300 mg/kg N/R HBTXAC 1,254,1955
subcutaneous
dog 		lowest published lethal dose: 300 mg/kg Behavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia 		VCVGK* -,238,1994
subcutaneous
frog 		lowest published lethal dose: 200 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Muscle weakness

Behavioral: Ataxia 		RMSRA6 15,561,1895
subcutaneous
guinea pig 		lowest published lethal dose: 800 mg/kg Behavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia 		VCVGK* -,238,1994
subcutaneous
man 		lowest published lethal dose: 120 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Gastrointestinal: Changes in structure or function of salivary glands 		ZMWIAJ 19,545,1881
subcutaneous
mouse 		lethal dose (50 percent kill): 566 mg/kg N/R ZGIMAL 2,333,1947
subcutaneous
rat 		lowest published lethal dose: 650 mg/kg N/R JAFCAU 17,497,1969
subcutaneous
rabbit 		lowest published lethal dose: 1 gm/kg N/R HBAMAK 4,1289,1935
subcutaneous
rabbit 		lowest published lethal dose: 1,000 mg/kg Behavioral: Tetany

Vascular: BP lowering not characterized in autonomic section

Blood: Other hemolysis with or without anemia 		VCVGK* -,238,1994
skin
mouse 		lowest published toxic dose: 5 pph Immunological Including Allergic: Anaphylaxis (multiple organ involvement) TOXID9 72,52,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
chicken 		lowest published toxic dose: 98 gm/kg/4 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field FEPRA7 29,568,1970
oral
rat 		lowest published toxic dose: 1,200 mg/kg/60 day- intermittent Blood: Changes in cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		VCVGK* -,238,1994
oral
rat 		lowest published toxic dose: 15,200 mg/kg/152 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		VCVGK* -,238,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 47,75,1978
TOXICOLOGY REVIEW
MUREAV 539,77,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81963;
Number of Industries 22;
Total Number of Facilities 848;
Number of Occupations 25;
Total Number of Employees Exposed 19,191
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81963;
Number of Industries 8;
Total Number of Facilities 2,175;
Number of Occupations 14;
Total Number of Employees Exposed 38,038;
Total Number of Female Employees Exposed 24,931


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a topical antibacterial agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AJVRAH American Journal of Veterinary Research. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917-
ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
ZGIMAL Zeitschrift fuer die Gesamte Innere Medizin und Ihre Grenzgebiete. (Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1946-
ZMWIAJ Znetralbaltt fuer die Medizinischen Wissenschaften. (Berlin, Germany)

Used as a topical antibacterial agent

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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