The Registry of Toxic Effects of Chemical Substances

Pyrophosphoric acid, tetraethyl ester

RTECS #: UX6825000

CAS #: 107-49-3

UPDATE: November 2004 MW: 290.22 MF: C8H20O7P2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Bis - O,O - diethylphosphoric anhydride
  2. Bladan
  3. Diphosphoric acid tetraethyl ester
  4. EA 1285
  5. ENT 18,771
  6. Ethyl pyrophosphate, tetra -
  7. Fosvex
  8. Grisol
  9. HEPT
  10. Hexamite
  11. Killex
  12. Kilmite 40
  13. Lethalaire G - 52
  14. Lirohex
  15. Mortopal
  16. Nifos
  17. Nifos T
  1. O,O,O,O - Tetraethyl - difosfaat (Dutch)
  2. O,O,O,O - Tetraetil - pirofosfato (Italian)
  3. Pyrophosphate de tetraethyle (French)
  4. RCRA waste number P111
  5. TEPP (ACGIH:OSHA)
  6. Tetraaethylpyrophosphorsaeureester (German)
  7. Tetraethyl diphosphate
  8. Tetraethyl pyrofosfaat (Dutch)
  9. Tetraethyl pyrophosphate
  10. Tetraethyl pyrophosphate (OSHA)
  11. Tetraethyldifosfat (Czech)
  12. Tetraethylpyrofosfat (Czech)
  13. Tetrastigmine
  14. Tetron
  15. Tetron - 100
  16. Vapotone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
human 		lowest published lethal dose: 286 µg/kg Peripheral Nerve and Sensation: Paresthesia

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting 		CMEP** -,1,1956
intramuscular
man 		lowest published lethal dose: 380 µg/kg N/R JCINAO 37,350,1958
intramuscular
rat 		lethal dose (50 percent kill): 1,800 µg/kg N/R JCINAO 37,350,1958
intraperitoneal
mouse 		lethal dose (50 percent kill): 830 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase AIPTAK 121,104,1959
intraperitoneal
rat 		lethal dose (50 percent kill): 650 µg/kg N/R FEPRA7 6,353,1947
intravenous
mouse 		lethal dose (50 percent kill): 200 µg/kg N/R BJPCAL 9,299,1954
intravenous
pigeon 		lethal dose (50 percent kill): 180 µg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Eye: Other eye effects 		AIPTAK 102,371,1955
intravenous
rat 		lethal dose (50 percent kill): 300 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases CJBPAZ 34,197,1956
intravenous
rabbit 		lowest published lethal dose: 300 µg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes 		BJPCAL 8,466,1953
oral
wild bird 		lethal dose (50 percent kill): 1,300 µg/kg N/R TXAPA9 21,315,1972
oral
duck 		lethal dose (50 percent kill): 3,560 µg/kg N/R TXAPA9 47,451,1979
oral
guinea pig 		lethal dose (50 percent kill): 2,300 µg/kg N/R JPETAB 105,156,1952
oral
human 		lowest published lethal dose: 1,429 µg/kg Peripheral Nerve and Sensation: Paresthesia

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting 		CMEP** -,1,1956
oral
human 		lowest published toxic dose: 309 µg/kg Behavioral: Wakefulness

Behavioral: Muscle contraction or spasticity

Gastrointestinal: Other changes 		CMEP** -,1,1956
oral
man 		lowest published lethal dose: 1,700 µg/kg N/R JCINAO 37,350,1958
oral
mouse 		lethal dose (50 percent kill): 3 mg/kg N/R ABCHA6 27,684,1963
oral
rat 		lethal dose (50 percent kill): 500 µg/kg N/R PHJOAV 185,361,1960
parenteral
frog 		lethal dose (50 percent kill): 34 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Other changes 		AIPTAK 124,212,1960
parenteral
human 		lowest published toxic dose: 71 µg/kg Behavioral: Wakefulness

Behavioral: Muscle contraction or spasticity

Gastrointestinal: Other changes 		CMEP** -,1,1956
subcutaneous
guinea pig 		lethal dose (50 percent kill): 700 µg/kg N/R BJPCAL 14,5,1959
subcutaneous
mouse 		lethal dose (50 percent kill): 500 µg/kg N/R ARZNAD 29,875,1979
subcutaneous
rat 		lethal dose (50 percent kill): 279 µg/kg N/R FAATDF 4,S195,1984
subcutaneous
rabbit 		lethal dose (50 percent kill): 2 mg/kg N/R IAEC** 17JUN1974
skin
duck 		lethal dose (50 percent kill): 64 mg/kg N/R TXAPA9 47,451,1979
skin
mouse 		lethal dose (50 percent kill): 8 mg/kg N/R ABCHA6 27,684,1963
skin
rat 		lethal dose (50 percent kill): 2,400 µg/kg N/R TXAPA9 14,515,1969
skin
rabbit 		lowest published lethal dose: 17 µL/kg Behavioral: Excitement

Gastrointestinal: Changes in structure or function of salivary glands

Lung, Thorax, or Respiration: Respiratory stimulation 		NTIS** OTS0534856
unreported route
rat 		lethal dose (50 percent kill): 1,120 µg/kg N/R 30ZDA9 -,379,1971
unreported route
rabbit 		lethal dose (50 percent kill): 1 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase AJOPAA 53,512,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (skin) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
CRTXB2 3,289,1975
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
IRXPAT 3,219,1964


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.004 ppm (0.05 mg/m3) DTLWS* 3,28,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.05 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.05 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.05 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.05 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.004 ppm (0.05 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.004 ppm (0.05 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.005 ppm (0.05 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.004 ppm (0.047 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.004 ppm (0.05 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.004 ppm (0.05 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.005 ppm (0.05 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.005 ppm (0.05 mg/m3), Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit UNITED KINGDOM;
time-weighted average 0.004 ppm (0.05 mg/m3), short term exposure limit 0.1 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 mg/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 mg/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TEPP-air 10 hour time-weighted average 0.05 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 71680;
Number of Industries 1;
Total Number of Facilities 9;
Number of Occupations 14;
Total Number of Employees Exposed 1,434


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tetraethyl pyrophosphate, 2504


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CJBPAZ Canadian Journal of Biochemistry and Physiology. (Ottawa, Ont., Canada) V.32-41, 1954-63. For publisher information, see CJBIAE.
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974
IRXPAT International Review of Experimental Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962-
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London, SE1 7JN, UK) V.131- 1933-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an insecticide to control aphids, thrips, and mites and as an anticholinesterase

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Human Data

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