The Registry of Toxic Effects of Chemical Substances

Pyrophosphoric acid, tetrasodium salt

RTECS #: UX7350000

CAS #: 7722-88-5

UPDATE: May 2004 MW: 265.90 MF: O7P2•4Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Anhydrous tetrasodium pyrophosphate
  2. Natrium pyrophosphat (German)
  3. Phosphotex
  4. Pyrophosphate
  5. TSPP
  6. Tetranatriumpyrophosphat (German)
  1. Tetrasodium diphosphate
  2. Tetrasodium pyrophosphate
  3. Tetrasodium pyrophosphate (ACGIH)
  4. Tetrasodium pyrophosphate, anhydrous
  5. Victor TSPP


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 59 mg/kg Behavioral: Excitement

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JPETAB 108,117,1953
intravenous
mouse 		lethal dose (50 percent kill): 69 mg/kg N/R ARZNAD 7,445,1957
intravenous
rat 		lethal dose (50 percent kill): 100 mg/kg N/R ARZNAD 7,172,1957
oral
mouse 		lethal dose (50 percent kill): 2,980 mg/kg N/R ARZNAD 7,445,1957
oral
rat 		lethal dose (50 percent kill): 4 gm/kg N/R ARZNAD 7,172,1957
subcutaneous
mouse 		lethal dose (50 percent kill): 400 mg/kg N/R ARZNAD 7,445,1957
skin
rabbit 		lethal dose : >300 mg/kg N/R ATDAEI 1,47,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
ARZNAD 7,24,1957


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,319,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRASODIUM PYROPHOSPHATE-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80224;
Number of Industries 179;
Total Number of Facilities 22,297;
Number of Occupations 108;
Total Number of Employees Exposed 177,064
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80224;
Number of Industries 223;
Total Number of Facilities 31,059;
Number of Occupations 144;
Total Number of Employees Exposed 566,370;
Total Number of Female Employees Exposed 244,801


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as water softener, a dispersing and emulsifying agent, a metal cleaner
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used as water softener, a dispersing and emulsifying agent, a metal cleaner

RTECS Compound Description:
   Drug

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