The Registry of Toxic Effects of Chemical Substances

Salicylic acid, acetate

RTECS #: VO0700000

CAS #: 50-78-2

UPDATE: May 2005 MW: 180.17 MF: C9H8O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - (Acetyloxy) benzoic acid
  2. 2 - Acetoxybenzoic acid
  3. A.S.A.
  4. A.S.A. empirin
  5. AC 5230
  6. ASA
  7. Acenterine
  8. Acesal
  9. Aceticyl
  10. Acetilsalicilico
  11. Acetilum acidulatum
  12. Acetisal
  13. Acetol
  14. Acetonyl
  15. Acetophen
  16. Acetosal
  17. Acetosalic acid
  18. Acetosalin
  19. Acetylin
  20. Acetylsal
  21. Acetylsalicylic acid
  22. Acetylsalicylic acid (ACGIH)
  23. Acetylsalicylsaure (German)
  24. Acide acetylsalicylique (French)
  25. Acido O - acetil - benzoico (Italian)
  26. Acido acetilsalicilico (Italian)
  27. Acidum acetylsalicylicum
  28. Acimetten
  29. Acisal
  30. Acylpyrin
  31. Asagran
  32. Aspergum
  33. Aspirdrops
  34. Aspirin
  35. Aspirina 03
  36. Aspro Clear
  37. Asteric
  38. Benaspir
  39. Benzoic acid, 2 - (acetyloxy) - (9CI)
  1. Bialpirinia
  2. Caprin
  3. Colfarit
  4. Contrheuma retard
  5. Delgesic
  6. Dolean pH 8
  7. Duramax
  8. ECM
  9. Ecotrin
  10. Empirin
  11. Endydol
  12. Entericin
  13. Enterosarine
  14. Entrophen
  15. Globoid
  16. Helicon
  17. Idragin
  18. Istopirin
  19. Kapsazal
  20. Kyselina 2 - acetoxybenzoova (Czech)
  21. Kyselina acetylsalicylova (Czech)
  22. Measurin
  23. Medisyl
  24. Micristin
  25. Neuronika
  26. Novid
  27. Polopiryna
  28. Rheumin tabletten
  29. Rhonal
  30. Salacetin
  31. Salcetogen
  32. Saletin
  33. Solpyron
  34. Triple - sal
  35. Xaxa
  36. Yasta
  37. Zorprin
  38. o - Acetoxybenzoic acid
  39. o - Carboxyphenyl acetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 1,660 mg/L GMCRDC 27,95,1981
cytogenetic analysis human fibroblast 100 mg/L ACYTAN 16,41,1972
cytogenetic analysis human leukocyte 100 µg/L SCIEAS 171,829,1971
cytogenetic analysis human lymphocyte 10 mg/L BEXBAN 78,1194,1974
DNA inhibition human lymphocyte 100 µmol/L FEPRA7 36,1748,1977
DNA repair Bacillus subtilis 5 mg/disc JNUDAT 34,183,1992
morphological transform rat embryo 108 µg/plate JJATDK 1,190,1981
other mutation test systems human lymphocyte 75 mg/L NEZAAQ 37,673,1982
sister chromatid exchange intraperitoneal
mouse 		100 mg/kg MUREAV 370,1,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intrauterine
rat 		lowest published toxic dose: 2 mg/kg (4 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) CCPTAY 24,283,1981
oral
cat 		lowest published toxic dose: 300 mg/kg (10-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 14,21,1976
oral
dog 		lowest published toxic dose: 3,200 mg/kg (23-30 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Respiratory system 		TJADAB 20,313,1979
oral
mouse 		lowest published toxic dose: 1,200 mg/kg (8-9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		LANCAO 1,606,1965
oral
mouse 		lowest published toxic dose: 800 mg/kg (17 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other effects to embryo or fetus

Reproductive: Other developmental abnormalities 		APTOA6 29,250,1971
oral
mouse 		lowest published toxic dose: 19,200 mg/kg (6-21 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Other neonatal measures or effects 		LANCAO 1,565,1964
oral
mouse 		lowest published toxic dose: 2,500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TXCYAC 37,315,1985
oral
rat 		lowest published toxic dose: 1 gm/kg (12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		TJADAB 27,261,1983
oral
rat 		lowest published toxic dose: 2,100 mg/kg (14 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct IJEBA6 18,1408,1980
oral
rat 		lowest published toxic dose: 500 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death ANREAK 163,175,1969
oral
rat 		lowest published toxic dose: 200 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 16,127,1977
oral
rat 		lowest published toxic dose: 10 mg/kg (22 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		NATUAS 240,21,1972
oral
rat 		lowest published toxic dose: 500 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ANREAK 163,175,1969
oral
rat 		lowest published toxic dose: 125 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 27,261,1983
oral
rat 		lowest published toxic dose: 1 gm/kg (3 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) YHHPAL 31,416,1996
oral
rabbit 		lowest published toxic dose: 800 mg/kg (8-15 day pregnant) Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		BANMAC 159,433,1975
oral
rabbit 		lowest published toxic dose: 1,800 mg/kg (8-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on embryo or fetus: Fetal death 		TXAPA9 10,244,1967
oral
rabbit 		lowest published toxic dose: 1,750 mg/kg (6-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) LANCAO 1,763,1964
oral
rabbit 		lowest published toxic dose: 600 mg/kg (2 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility JJPAAZ 28,909,1978
oral
woman 		lowest published toxic dose: 7,500 mg/kg (34-37 week pregnant) Reproductive: Other effects on female

Reproductive: Effects on newborn: Stillbirth 		AJPEEK 15,39,1998
oral
woman 		lowest published toxic dose: 700 mg/kg (35-36 week pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on newborn: Biochemical and metabolic 		CPEDAM 34,174,1995
oral
woman 		lowest published toxic dose: 546 mg/kg (37-39 week pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects CPEDAM 32,740,1993
oral
woman 		lowest published toxic dose: 546 mg/kg (37-39 week pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Other developmental abnormalities 		CPEDAM 32,740,1993
oral
woman 		lowest published toxic dose: 17,550 mg/kg (12-39 week pregnant) Reproductive: Maternal effects: Parturition LANCAO 2,1159,1973
oral
woman 		lowest published toxic dose: 100 mg/kg (37 week pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects NEJMAG 307,909,1982
oral
woman 		lowest published toxic dose: 17,280 mg/kg (1-39 week pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Effects on newborn: Apgar score (human only) 		JOPDAB 92,478,1978
oral
woman 		lowest published toxic dose: 189 mg/kg (12-39 week pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) 		NEJMAG 321,357,1989
subcutaneous
mouse 		lowest published toxic dose: 500 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JTSCDR 7,177,1982
subcutaneous
rat 		lowest published toxic dose: 1,800 mg/kg (12 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		INJFA3 23,282,1978
subcutaneous
rat 		lowest published toxic dose: 380 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities 		BCPCA6 22,407,1973
subcutaneous
rat 		lowest published toxic dose: 500 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		RCOCB8 38,209,1982
subcutaneous
rat 		lowest published toxic dose: 500 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system RCOCB8 38,209,1982
subcutaneous
rat 		lowest published toxic dose: 500 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		RCOCB8 39,179,1983
subcutaneous
rat 		lowest published toxic dose: 300 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility PRGLBA 1,3,1972
unreported route
dog 		lowest published toxic dose: 3 gm/kg (20-34 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death JZKEDZ 6,37,1980
unreported route
rat 		lowest published toxic dose: 3,500 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities 		JACTDZ 2(4),325,1983
unreported route
rabbit 		lowest published toxic dose: 11,250 mg/kg (16-30 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death AKGIAO 43(12),10,1967
unreported route
woman 		lowest published toxic dose: 1,200 mg/kg (20 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders CCPTAY 29,181,1984


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 167 mg/kg N/R USXXAM #4376771
intraperitoneal
mouse 		lowest published lethal dose: 1,216 mg/kg N/R PCJOAU 34,353,2000
intraperitoneal
mouse 		lowest published toxic dose: 50 mg/kg Behavioral: Analgesia FRMCE8 58,25,2003
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg Gastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin) 		EJPHAZ 460,63,2003
intraperitoneal
rat 		lethal dose (50 percent kill): 340 mg/kg N/R NYKZAU 62,11,1966
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation BJPCBM 129,343,2000
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg Behavioral: Analgesia BJPCBM 129,343,2000
intraperitoneal
rat 		lowest published toxic dose: 500 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		EKFAE9 59,43,1996
intravenous
dog 		lethal dose (50 percent kill): 681 mg/kg Behavioral: Analgesia AIPTAK 149,571,1964
intravenous
guinea pig 		lowest published toxic dose: 100 mg/kg Blood: Change in clotting factors JPETAB 298,34,2001
intravenous
mouse 		lowest published toxic dose: 10 mg/kg Vascular: Measurement of regional blood flow EJPHAZ 455,53,2002
intravenous
rat 		lethal dose (50 percent kill): 495 mg/kg N/R GWXXAW #4101325
oral
child 		lowest published toxic dose: 10 mg/kg/1 day- intermittent Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Urine volume decreased or anuria 		CTOXAO 18,247,1981
oral
child 		lowest published lethal dose: 104 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Nausea or vomiting

Blood: Hemorrhage 		LANCAO 2,809,1952
oral
child 		lowest published toxic dose: 39 mg/kg/13 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse AJDCAI 139,453,1985
oral
dog 		lethal dose (50 percent kill): 700 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression 		ARZNAD 21,719,1971
oral
guinea pig 		lethal dose (50 percent kill): 1,075 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor 		JAPMA8 47,479,1958
oral
hamster 		lethal dose (50 percent kill): 3,500 mg/kg N/R ATSUDG 7,365,1984
oral
human 		lowest published toxic dose: 669 mg/kg/11 day Liver: Liver function tests impaired AJHPA9 35,330,1978
oral
human 		lowest published toxic dose: 2,880 mg/kg/8 week Ear: Tinnitus

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Decreased motility or constipation 		ARZNAD 33,631,1983
oral
human 		lowest published toxic dose: 480 mg/kg/7 day- intermittent Ear: Tinnitus

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes 		ARZNAD 25,281,1975
oral
human 		lowest published toxic dose: 1,050 mg/kg/14 day- intermittent Vascular: Other changes CLPTAT 67,530,2000
oral
human 		lowest published toxic dose: 5.4 mg/kg Vascular: Other changes

Blood: Other changes 		CLPTAT 67,299,2000
oral
infant 		lowest published toxic dose: 120 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Hematuria

Nutritional and Gross Metabolic: Dehydration 		BMJOAE 1,1081,1979
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 1,750 mg/kg N/R IJMRAQ 81,621,1985
oral
man 		lowest published toxic dose: 13,036 mg/kg/5 year- intermittent Gastrointestinal: Other changes

Musculoskeletal: Joints

Skin: After systemic exposure: Dermatitis, other 		AIMEAS 126,665,1997
oral
man 		lowest published toxic dose: 857 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation 		HUTODJ 7,161,1988
oral
man 		lowest published toxic dose: 1,625 mg/kg Behavioral: Coma

Nutritional and Gross Metabolic: Body temperature increase 		CPEDAM 24,678,1985
oral
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R ARZNAD 5,572,1955
oral
mouse 		lowest published toxic dose: 90 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation FATOAO 54,47,1991
oral
mouse 		lowest published toxic dose: 300 mg/kg Gastrointestinal: Ulceration or bleeding from stomach PCJOAU 36,11,2002
oral
mouse 		lowest published toxic dose: 23 mg/kg Behavioral: Analgesia JPETAB 303,340,2002
oral
mouse 		lowest published toxic dose: 200 mg/kg Gastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin) 		EJPHAZ 460,63,2003
oral
rat 		lethal dose (50 percent kill): 200 mg/kg N/R 34ZIAG -,67,1969
oral
rat 		lowest published toxic dose: 150 mg/kg Behavioral: Abuse INJPD2 33,350,2001
oral
rat 		lowest published toxic dose: 300 mg/kg Gastrointestinal: Ulceration or bleeding from stomach FATOAO 49,81,1986
oral
rat 		lowest published toxic dose: 17 mg/kg Behavioral: Analgesia FATOAO 51,78,1988
oral
rat 		lowest published toxic dose: 250 mg/kg Gastrointestinal: Alteration in gastric secretion

Gastrointestinal: Ulceration or bleeding from stomach 		FCLPH* 16,311,2002
oral
rat 		lowest published toxic dose: 50 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation FRMCE8 59,255,2004
oral
rabbit 		lethal dose (50 percent kill): 1,010 mg/kg Behavioral: Change in motor activity (specific assay) GTPZAB 24(3),43,1980
oral
woman 		lowest published toxic dose: 525 mg/kg/5 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse AIMEAS 80,74,1974
oral
woman 		lowest published toxic dose: 480 mg/kg/5 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Metabolism (intermediary): Other 		NEJMAG 296,418,1977
oral
woman 		lowest published toxic dose: 800 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Musculoskeletal: Other changes 		AJEMEN 7,409,1989
oral
woman 		lowest published toxic dose: 194.4 mg/kg Ear: Tinnitus

Gastrointestinal: Nausea or vomiting 		APHRER 38,1186,2004
rectal
rat 		lethal dose (50 percent kill): 790 mg/kg N/R 34ZIAG -,67,1969
rectal
woman 		lowest published toxic dose: 4,550 mg/kg Brain and Coverings: Encephalitis

Behavioral: Coma

Cardiac: Arrythmias (indlucing changes in conduction) 		APHRER 28,467,1994
subcutaneous
mouse 		lethal dose (50 percent kill): 1,020 mg/kg N/R CPBTAL 28,1237,1980
skin
mouse 		lowest published toxic dose: 50 mg/kg Immunological Including Allergic: Decrease in cellular immune response FATOAO 47,84,1984
skin
rat 		lowest published toxic dose: 50 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation FATOAO 47,84,1984
unreported route
man 		lowest published lethal dose: 294 mg/kg N/R 85DCAI 2,73,1970
unreported route
mouse 		lethal dose (50 percent kill): 1,350 mg/kg N/R USXXAM #5240918


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 25 mg/m3/4 hour/17 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Change in clotting factors

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		GTPZAB 24(3),43,1980
intraperitoneal
rat 		lowest published toxic dose: 8,750 mg/kg/21 day- intermittent Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli JDGRAX 19,327,1990
oral
dog 		lowest published toxic dose: 1,200 mg/kg/2 day- intermittent Blood: Change in clotting factors FATOBP 159,19,1986
oral
dog 		lowest published toxic dose: 12,000 mg/kg/10 day- intermittent Blood: Change in clotting factors FATOAO 49,49,1986
oral
human 		lowest published toxic dose: 85.8 mg/kg/30 day- intermittent Gastrointestinal: Ulceration or bleeding from duodeum NEJMAG 343,834,2000
oral
human 		lowest published toxic dose: 10 mg/kg/7 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach EJCPAS -,S85,2002
oral
rat 		lowest published toxic dose: 200 mg/kg/4 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach TXAPA9 52,454,1980
oral
rat 		lowest published toxic dose: 8,127 mg/kg/43 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition APTOA6 26,105,1968
oral
rat 		lowest published toxic dose: 9,500 mg/kg/3 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JPETAB 89,205,1947
oral
rat 		lowest published toxic dose: 2,500 mg/kg/10 day- intermittent Endocrine: Hypoglycemia

Blood: Other changes 		FATOBP 159,75,1986
oral
rat 		lowest published toxic dose: 5,000 mg/kg/10 day- intermittent Endocrine: Other changes

Blood: Other changes 		FATOBP 159,75,1986
oral
rat 		lowest published toxic dose: 32.4 mg/kg/3 day- intermittent Blood: Change in clotting factors EKFAE9 62,38,1999
oral
rat 		lowest published toxic dose: 560 mg/kg/4 week- continuous Skin and Appendages: Tumors

Tumorigenic: Protects against induction of experimental tumors

Tumorigenic: Active as anti-cancer agent 		CALEDQ 143,195,1999
oral
rat 		lowest published toxic dose: 1,500 mg/kg/2 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXCYAC 188,161,2003
oral
rat 		lowest published toxic dose: 180 mg/kg/10 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) EJPHAZ 477,59,2003
oral
woman 		lowest published toxic dose: 0.36 mg/kg/24 week- intermittent Lung, Thorax, or Respiration: Tumors BJCAAI 87,49,2002
subcutaneous
mouse 		lowest published toxic dose: 2,520 mg/kg/3 week- continuous Endocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		SCIEAS 293,1673,2001
subcutaneous
rat 		lowest published toxic dose: 840 mg/kg/1 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport 		SCIEAS 293,1673,2001
subcutaneous
rat 		lowest published toxic dose: 2,520 mg/kg/3 week- continuous Endocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport 		SCIEAS 293,1673,2001
skin
mouse 		lowest published toxic dose: 500 mg/kg/10 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation FATOAO 47,84,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
JJIND8 94,252,2002
TOXICOLOGY REVIEW
REPTED 17,255,2003
TOXICOLOGY REVIEW
DICPBB 8,690,1974
TOXICOLOGY REVIEW
PLMJAP 6,160,1975
TOXICOLOGY REVIEW
JPHAA3 NS16,147,1976
TOXICOLOGY REVIEW
AUHPAI 3(3),100,1973
TOXICOLOGY REVIEW
JRPMAP 12,27,1974
TOXICOLOGY REVIEW
CLCHAU 19,361,1973
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
ATXKA8 28,135,1971
TOXICOLOGY REVIEW
AIMDAP 141,358,1981
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
TOLED5 144,383,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,351,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 gm/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACETYLSALICYLIC ACID-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84517;
Number of Industries 12;
Total Number of Facilities 1,746;
Number of Occupations 16;
Total Number of Employees Exposed 10,452
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1189;
Number of Industries 1;
Total Number of Facilities 27;
Number of Occupations 1;
Total Number of Employees Exposed 191;
Total Number of Female Employees Exposed 82
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84517;
Number of Industries 9;
Total Number of Facilities 491;
Number of Occupations 22;
Total Number of Employees Exposed 10,776;
Total Number of Female Employees Exposed 6,083


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a pharmaceutical and veterinary drug
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
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Used as a pharmaceutical and veterinary drug

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 2349-94-2
ALT CAS #: 11126-35-5
ALT CAS #: 11126-37-7
ALT CAS #: 26914-13-6
ALT CAS #: 98201-60-6
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