The Registry of Toxic Effects of Chemical Substances

Selenium

RTECS #: VS7700000

CAS #: 7782-49-2

UPDATE: November 2004 MW: 78.96 MF: Se


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. C.I. 77805
  2. Colloidal selenium
  3. Elemental selenium
  4. Selen (Polish)
  5. Selenium base
  6. Selenium dust
  1. Selenium elemental
  2. Selenium homopolymer
  3. Selenium (ACGIH)
  4. Selenium alloy
  5. Selenate
  6. Vandex


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 134 mg/kg (multigenerations) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		AEHLAU 23,102,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 480 mg/kg/60 day- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		YMBUA7 11,368,1960


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 33 mg/m3/8 hour Blood: Hemorrhage

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Changes in lung weight 		AMIHBC 4,458,1951
intravenous
rat 		lethal dose (50 percent kill): 6 mg/kg N/R AMIHBC 4,458,1951
intravenous
rabbit 		lowest published lethal dose: 2,500 µg/kg N/R JOBSAK 35,693,1928
oral
rat 		lethal dose (50 percent kill): 6,700 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Other changes 		TXAPA9 20,89,1971
parenteral
cattle 		lowest published lethal dose: 0.5 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		VCVN5* -,268,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
human 		lowest published toxic dose: 23.7 mg/kg/13 week- continuous Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Skin and Appendages: Other: Nails 		VCVN5* -,273,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Se)/m3 DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 9,245,1975
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 9,245,1975
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
CTOXAO 6,459,1973
TOXICOLOGY REVIEW
CTOXAO 5,175,1972
TOXICOLOGY REVIEW
CRTXB2 4(3),271,1976
TOXICOLOGY REVIEW
JAVMA4 164,277,1974
TOXICOLOGY REVIEW
CTOXAO 5,151,1972
TOXICOLOGY REVIEW
IJMDAI 10,416,1974
TOXICOLOGY REVIEW
JAMAAP 116,562,1941
TOXICOLOGY REVIEW
CHREAY 28,179,1941
TOXICOLOGY REVIEW
ADTEAS 5,51,1972
TOXICOLOGY REVIEW
PHREA7 23,305,1943
TOXICOLOGY REVIEW
FOREAE 7,313,1942
TOXICOLOGY REVIEW
KOTTAM 11,1300,1975
TOXICOLOGY REVIEW
85CVA2 5,63,1970
TOXICOLOGY REVIEW
PEXTAR 12,102,1969
TOXICOLOGY REVIEW
BNYMAM 54,413,1978
TOXICOLOGY REVIEW
AMTODM 3,209,1977
TOXICOLOGY REVIEW
JEPTDQ 4(1),193,1980
TOXICOLOGY REVIEW
MEHYDY 5,877,1979
TOXICOLOGY REVIEW
CTOXAO 17,171,1980
TOXICOLOGY REVIEW
JACTDZ 5(1),45,1986
TOXICOLOGY REVIEW
TOLED5 137,103,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg(Se)/m3 DTLVS* 3,224,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 mg/m3, JAN1993
Occupational Exposure Limit - HUNGARY short term exposure limit 0.1 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg(Se)/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.3 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.1 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg(Se)/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg(Se)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SELENIUM COMPOUNDS (as Se)-air 10 hour time-weighted average 0.2 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 68295;
Number of Industries 8;
Total Number of Facilities 403;
Number of Occupations 10;
Total Number of Employees Exposed 2,147
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2074;
Number of Industries 2;
Total Number of Facilities 105;
Number of Occupations 2;
Total Number of Employees Exposed 105
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 68295;
Number of Industries 23;
Total Number of Facilities 1,102;
Number of Occupations 68;
Total Number of Employees Exposed 27,208;
Total Number of Female Employees Exposed 9,632


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121032/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in pigments, photoelectric cells, metallurgy and electronics
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements by ICP, 7300
OSHA ANALYTICAL METHOD #ID-125G


REFERENCES:

CODEN
REFERENCE
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued.
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AMTODM Advances in Modern Toxicology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10016) V.1, 1976-79. Discontinued.
BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013, Israel) V.1- 1965-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JOBSAK Journal of Obstetrics and Gynaecology of the British Empire. (London, UK) V.1-27, 1902-15; V.28-67, 1921-60. For publisher information, see BJOGAS.
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
MEHYDY Medical Hypotheses. (Churchill Livingstone Inc., 1560 Broadway, New York, NY 10036) V.1- 1975-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960-
PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
YMBUA7 Yokohama Medical Bulletin. (Yokohama City Univ. School of Medicine, 2-33, Yokohama 232, Japan) V.1- 1950-

Used in pigments, photoelectric cells, metallurgy and electronics

NIOSH PROFILE (SELENIUM AND ITS COMPOUND), SRC, 4/78

NIOSH PROFILE (TIRE MANUFACTURING), SRI, 2/77

NIOSH PROFILE (TIRE MANUFACTURING), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Human Data

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