The Registry of Toxic Effects of Chemical Substances

Selenium (IV) dioxide (1:2)

RTECS #: VS8575000

CAS #: 7446-08-4

UPDATE: May 2004 MW: 110.96 MF: O2Se


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Selenious anhydride
  2. RCRA waste number U204
  1. Selenium oxide (1:2)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 10 mmol/L MUREAV 77,109,1980
micronucleus test other fish leukocyte 50 µg/L MUREAV 320,157,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 2,160 µg/kg (90 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct IJPPAZ 27,237,1983
subcutaneous
gerbil 		lowest published toxic dose: 5,600 µg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		JRMSAS 85,297,1965


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 60 mg/m3 Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,267,1993
intraperitoneal
mouse 		lethal dose (50 percent kill): 4,300 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		INJPD2 23,153,1991
intraperitoneal
rat 		lethal dose (50 percent kill): 3,600 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		INJPD2 23,153,1991
intratracheal
rat 		lowest published lethal dose: 7.5 mg/kg N/R VCVN5* -,266,1993
intratracheal
rat 		lowest published lethal dose: 7.5 mg/kg Lung, Thorax, or Respiration: Other changes VCVN5* -,267,1993
intravenous
mouse 		lethal dose (50 percent kill): 9,200 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		INJPD2 23,153,1991
intravenous
rat 		lethal dose (50 percent kill): 2,710 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		INJPD2 23,153,1991
oral
mouse 		lethal dose (50 percent kill): 23,300 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		INJPD2 23,153,1991
oral
rat 		lethal dose (50 percent kill): 68,100 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		INJPD2 23,153,1991
subcutaneous
gerbil 		lowest published lethal dose: 7,500 µg/kg N/R JRMSAS 85,297,1965
subcutaneous
mouse 		lowest published lethal dose: 0.5 mg/kg N/R VCVN5* -,266,1993
subcutaneous
rabbit 		lethal dose (50 percent kill): 4 mg/kg N/R VCVN5* -,266,1993
subcutaneous
rabbit 		lowest published lethal dose: 0.5 mg/kg N/R VCVN5* -,266,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 3 mg/m3/6 hour/4 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVN5* -,271,1989
inhalation
rat 		lowest published toxic concentration: 5,500 ng/kg/13 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		GISAAA 40(10),14,1975
oral
domestic animal 		lowest published toxic dose: 780 µg/kg/26 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		EVMJB9 46,189,1986
oral
rat 		lowest published toxic dose: 160 mg/kg/40 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count 		KHZDAN 13,174,1970


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Se)/m3 DTLVS* TLV/BEI,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg(Se)/m3 DTLVS* 3,224,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg(Se)/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg(Se)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.3 mg(Se)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 mg(Se)/m3, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 0.1 mg(Se)/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg(Se)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg(Se)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg(Se)/m3, MAC(short term exposure limit) 0.3 mg(Se)/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.1 mg(Se)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Se)/m3, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.2 mg(Se)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(Se)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg(Se)/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg(Se)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84447;
Number of Industries 5;
Total Number of Facilities 225;
Number of Occupations 6;
Total Number of Employees Exposed 795
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84447;
Number of Industries 10;
Total Number of Facilities 237;
Number of Occupations 17;
Total Number of Employees Exposed 5,207;
Total Number of Female Employees Exposed 823


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVMJB9 Journal of the Egyptian Veterinary Medical Association. (Egyptian Veterinary Medical Association, 8, 26 July St., Cairo, Egypt) V.27- 1967-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IJPPAZ Indian Journal of Physiology and Pharmacology. (All India Institute of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029, India) V.1- 1957-
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
JRMSAS Journal of the Royal Microscopical Society. (London, UK) V.47-88, 1927-68. For publisher information, see JMICAR.
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as oxidizing agent in synthesis of organic chemicals and pharmaceuticals

NIOSH PROFILE (SELENIUM AND ITS COMPOUND), SRC, 4/78

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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