The Registry of Toxic Effects of Chemical Substances

Silane, methyltrichloro -

RTECS #: VV4550000

CAS #: 75-79-6

UPDATE: September 2000 MW: 149.48 MF: CH3Cl3Si


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Methylsilicochloroform
  2. Methylsilyl trichloride
  3. Methyl - trichlorsilan (Czech)
  4. KA 13
  5. LS 40 (silane)
  1. Methylsilicon trichloride
  2. Trichlor - methylsilan (Czech)
  3. Trichloromethylsilicon
  4. Silane, trichloromethyl -
  5. Trichloromethylsilane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 mg/24 hour severe 85JCAE -,1219,1986
skin
rabbit 		500 µL severe ATDAEI 12,571,1993


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 180 mg/m3/2 hour N/R TPKVAL 3,23,1961
inhalation
rat 		lethal concentration (50 percent kill): 450 ppm/4 hour N/R 85JCAE -,1219,1986
intraperitoneal
rat 		lowest published lethal dose: 30 mg/kg N/R JIHTAB 30,332,1948
oral
rat 		lethal dose (50 percent kill): 1,620 µL/kg Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes 		ATDAEI 12,571,1993
skin
rabbit 		lethal dose (50 percent kill): 840 µL/kg Behavioral: Altered sleep time (including change in righting reflex)

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ATDAEI 12,571,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83302;
Number of Industries 1;
Total Number of Facilities 10;
Number of Occupations 1;
Total Number of Employees Exposed 60
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83302;
Number of Industries 2;
Total Number of Facilities 63;
Number of Occupations 6;
Total Number of Employees Exposed 1,755;
Total Number of Female Employees Exposed 1,191


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used as intermediate in production of silicones

NIOSH PROFILE (SILICON COMPOUNDS, ORGANIC), SRC, 12/79

RTECS Compound Description:
   Primary Irritant

ALT CAS #: 175446-71-6
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