The Registry of Toxic Effects of Chemical Substances

Sodium carbonate (2:1)

RTECS #: VZ4050000

CAS #: 497-19-8

UPDATE: August 2003 MW: 105.99 MF: CO3•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Bisodium carbonate
  2. Calcined soda
  3. Carbonic acid, disodium salt
  4. Crystol carbonate
  5. Disodium carbonate
  1. Snowlite 1
  2. Soda ash
  3. Sodium carbonate
  4. Solvay soda


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/24 hour moderate 28ZPAK -,8,1972
eye
rabbit 		100 mg/30S rinse mild TXCYAC 23,281,1982
eye
rabbit 		50 mg severe GTPZAB 20(11),55,1976
skin
rabbit 		500 mg/24 hour mild 28ZPAK -,7,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intrauterine
mouse 		lowest published toxic dose: 84,800 ng/kg (4 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) JRPFA4 63,365,1981


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		lowest published toxic dose: 25 mg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Cyanosis 		VCVN1* -,38,1998
inhalation
guinea pig 		lethal concentration (50 percent kill): 800 mg/m3/2 hour Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes 		ENVRAL 31,138,1983
inhalation
human 		lowest published toxic concentration: 40 mg/m3/1 minute Eye: Lacrimation

Eye: Conjunctiva irritation 		VCVN1* -,38,1998
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 100 mg/m3/4 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVN1* -,38,1998
inhalation
mouse 		lethal concentration (50 percent kill): 1,200 mg/m3/2 hour Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes 		ENVRAL 31,138,1983
inhalation
rat 		lethal concentration (50 percent kill): 2,300 mg/m3/2 hour Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes 		ENVRAL 31,138,1983
intraperitoneal
mouse 		lethal dose (50 percent kill): 117 mg/kg N/R COREAF 257,791,1963
oral
man 		lowest published lethal dose: 714 mg/kg Behavioral: General anesthetic

Gastrointestinal: Ulceration or bleeding from small intestine

Gastrointestinal: Other changes 		YAKUD5 32,570,1990
oral
mouse 		lethal dose (50 percent kill): 6,600 mg/kg N/R GTPZAB 20(11),55,1976
oral
mouse 		lethal dose (50 percent kill): 6,600 mg/kg Olfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Dyspnea 		VCVN1* -,37,1998
oral
rat 		lethal dose (50 percent kill): 4,090 mg/kg N/R 28ZPAK -,8,1972
subcutaneous
mouse 		lethal dose (50 percent kill): 2,210 mg/kg N/R VCVN1* -,36,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 16,200 µg/m3/17 week- intermittent Olfaction: Change in sensation of smell

Vascular: BP elevation not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression 		GTPZAB 20(11),55,1976
inhalation
rat 		lowest published toxic concentration: 16.2 mg/m3/16 week- intermittent Olfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Emphysema

Immunological Including Allergic: Decrease in cellular immune response 		VCVN1* -,38,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Unsupported RBREV* -,326,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 68850;
Number of Industries 389;
Total Number of Facilities 148,455;
Number of Occupations 193;
Total Number of Employees Exposed 1,143,671
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 68850;
Number of Industries 385;
Total Number of Facilities 97,764;
Number of Occupations 220;
Total Number of Employees Exposed 2,001,842;
Total Number of Female Employees Exposed 761,463


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of glass, detergent and soap, pond sealing, alkali in food and pulp
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used in the manufacture of glass, detergent and soap, pond sealing, alkali in food and pulp

Top 50 chemical production: 20.89 billions lbs in 1992, 19.86 billions in 1991

NIOSH PROFILE (ALUMINUM REDUCTION PLANTS), FIRL, 4/78

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

NIOSH PROFILE (SOLDER, MANUFACTURE AND USE), FIRL, 4/78

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 1332-57-6
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