The Registry of Toxic Effects of Chemical Substances

Sodium chlorite

RTECS #: VZ4800000

CAS #: 7758-19-2

UPDATE: August 2003 MW: 91.45 MF: ClHO2•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Alcide LD
  2. Chlorous acid, sodium salt (8CI,9CI)
  3. Neo Silox D
  1. Textile
  2. Textone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 20 mg/L FCTOD7 22,623,1984
DNA inhibition oral
rat 		84 mg/kg/12 week- continuous JEPOEC 6(1),105,1985
mutation in microorganisms Salmonella typhimurium 300 µg/plate (-enzymatic activation step) FCTOD7 22,623,1984
micronucleus test intraperitoneal
mouse 		15 mg/kg FCTOD7 26,487,1988
sperm morphology oral
rat 		660 mg/kg/66 day- continuous ENVRAL 42,238,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 160 mg/kg (8-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) EVHPAZ 46,25,1982
intraperitoneal
rat 		lowest published toxic dose: 80 mg/kg (8-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) EVHPAZ 46,25,1982
oral
mouse 		lowest published toxic dose: 22 gm/kg (1-21 day pregnant/28 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) BECTA6 25,689,1980
oral
rat 		lowest published toxic dose: 800 mg/kg (8-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) EVHPAZ 46,25,1982
oral
rat 		lowest published toxic dose: 16 gm/kg (8-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) EVHPAZ 46,25,1982
oral
rat 		lowest published toxic dose: 660 mg/kg (66 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) ENVRAL 42,238,1987
oral
rat 		lowest published toxic dose: 1,130 mg/kg (8 week male/2 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Biochemical and metabolic TJADAB 35,43A,1987
oral
rat 		lowest published toxic dose: 2.1 gm/kg (10 week male/10 week prior to copulation-4 week after birth) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Effects on newborn: Physical 		JJATDK 20,291,2000
oral
rat 		lowest published toxic dose: 8 gm/kg (10 week male/10 week prior to copulation-25 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JJATDK 20,291,2000
oral
rat 		lowest published toxic dose: 9 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) JJATDK 20,291,2000
oral
rat 		lowest published toxic dose: 69 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical 		JJATDK 20,291,2000


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 29,750 mg/kg/85 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		EVHPAZ 69,221,1986


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 230 mg/m3/4 hour N/R NTIS** OTS0534543
oral
guinea pig 		lethal dose (50 percent kill): 300 mg/kg N/R GISAAA 45(4),6,1980
oral
guinea pig 		lethal dose (50 percent kill): 300 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVN1* -,36,1998
oral
man 		lowest published toxic dose: 143 mg/kg Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		REFAE8 15,645,1993
oral
mouse 		lethal dose (50 percent kill): 350 mg/kg N/R VCVN1* -,36,1998
oral
rat 		lethal dose (50 percent kill): 165 mg/kg Liver: Jaundice, other or unclassified

Kidney, Ureter, and Bladder: Interstitial nephritis

Biochemical: Metabolism (intermediary): Other 		YKYUA6 31,959,1980
oral
rat 		lowest published toxic dose: 200 mg/kg Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands REPTED 6,491,1992
oral
rat 		lethal dose (50 percent kill): 350 mg/kg N/R VCVN1* -,36,1998
unreported route
mouse 		lowest published lethal dose: 300 mg/kg N/R VCVN1* -,39,1998
unreported route
rat 		lowest published lethal dose: 300 mg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Cyanosis 		VCVN1* -,39,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 168 mg/kg/28 day- continuous Immunological Including Allergic: Uncharacterized (multiple organ involvement) TOXID9 54,157,2000
oral
rat 		lowest published toxic dose: 365 mg/kg/1 year- continuous Blood: Pigmented or nucleated red blood cells

Blood: Changes in other cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JEPOEC 6(1),105,1985
oral
rat 		lowest published toxic dose: 182 gm/kg/26 week- intermittent Liver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		GISAAA 45(4),6,1980
oral
rat 		lowest published toxic dose: 2,730 mg/kg/10 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain JJATDK 20,291,2000
oral
rat 		lowest published toxic dose: 280 mg/kg/10 week- continuous Behavioral: Fluid intake JJATDK 20,291,2000
oral
rat 		lowest published toxic dose: 168 mg/kg/24 week- intermittent Cardiac: Cardiomyopathy including infarction

Liver: Changes in liver weight

Immunological Including Allergic: Decrease in cellular immune response 		VCVN1* -,40,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 52,145,1991
International Agency for Research on Cancer (IARC) Cancer Review Human No Available Data IMEMDT 52,145,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 52,145,1991


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,301,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81982;
Number of Industries 8;
Total Number of Facilities 129;
Number of Occupations 13;
Total Number of Employees Exposed 1,968
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81982;
Number of Industries 20;
Total Number of Facilities 532;
Number of Occupations 27;
Total Number of Employees Exposed 18,585;
Total Number of Female Employees Exposed 4,817


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as bleaching agent for textiles, paper pulp, edible oils
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REFAE8 Renal Failure. (Marcel Dekker Journals, POB 5005, Monticello, NY 12701) V.10- 1987-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as bleaching agent for textiles, paper pulp, edible oils

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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