The Registry of Toxic Effects of Chemical Substances

Sodium (I) nitrate (1:1)

RTECS #: WC5600000

CAS #: 7631-99-4

UPDATE: August 2003 MW: 85.00 MF: NO3•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Chile saltpeter
  2. Cubic niter
  3. Nitrate de sodium (French)
  4. Nitratine
  1. Nitric acid, sodium salt
  2. Soda niter
  3. Sodium nitrate
  4. Sodium saltpeter


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 7,200 mg/L/48 hour MUREAV 48,337,1977
cytogenetic analysis hamster lung 5,700 mg/L GMCRDC 27,95,1981
cytogenetic analysis oral
mouse 		7,067 mg/kg MUREAV 155,121,1985
cytogenetic analysis oral
rat 		78,500 µg/kg MUREAV 155,121,1985
unscheduled DNA synthesis human HeLa cell 6 mmol/L AEMBAP 177,269,1984
host-mediated assay hamster
embryo 		125 mg/kg MUREAV 66,149,1979
mutation in microorganisms other microorganisms 1,000 ppm (-enzymatic activation step) POASAD 34,114,1953
micronucleus test oral
hamster 		250 mg/kg MUREAV 66,149,1979
micronucleus test oral
mouse 		78,500 µg/kg MUREAV 155,121,1985
morphological transform oral
hamster 		250 mg/kg MUREAV 66,149,1979
morphological transform oral
rat 		13 gm/kg/6 week CRNGDP 9,387,1988
phage inhibition capacity Escherichia coli 133 µg/well MUREAV 260,349,1991
sperm morphology oral
mouse 		16,800 mg/kg/2 week MUREAV 204,689,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 16,800 mg/kg (14 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MUREAV 204,689,1988


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 100 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		FCTOD7 22,715,1984
oral
rat 		toxic dose : 1,825 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Testicular tumors 		FCTOD7 20,25,1982
oral
rat 		toxic dose : 913 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Testicular tumors 		FCTOD7 20,25,1982


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose : >181 mg/kg N/R TXAPA9 5,750,1963
intravenous
mouse 		lethal dose (50 percent kill): 175 mg/kg N/R ATXKA8 21,89,1965
oral
child 		lowest published lethal dose: 22,500 µg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia JTCTDW 32,173,1994
oral
mouse 		lethal dose (50 percent kill): 3,500 mg/kg N/R VCVN5* -,49,1993
oral
pig 		lowest published toxic dose: 0.5 gm/kg Behavioral: Change in psychophysiological tests

Behavioral: Food intake (animal)

Blood: Methemoglobinemia- Carboxhemoglobinemia 		GISAAA -,30,1993
oral
rat 		lethal dose (50 percent kill): 1,267 mg/kg N/R GISAAA 46(12),66,1981
oral
rabbit 		lethal dose (50 percent kill): 2,680 mg/kg N/R SOVEA7 27,246,1974
oral
woman 		lowest published toxic dose: 14 mg/kg Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia 		JTCTDW 32,173,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
pig 		lowest published toxic dose: 3.5 gm/kg/1 week- continuous Blood: Methemoglobinemia- Carboxhemoglobinemia GISAAA -,30,1993
oral
pig 		lowest published toxic dose: 28 gm/kg/8 week- continuous Gastrointestinal: Gastritis GISAAA -,30,1993
oral
rat 		lowest published toxic dose: 118 gm/kg/39 week- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TOLED5 17,125,1983
oral
rat 		lowest published toxic dose: 386 gm/kg/61 week- continuous Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOLED5 6,199,1980
oral
rat 		lowest published toxic dose: 1,224 mg/kg/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases 		VCVN5* -,50,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,318,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 69220;
Number of Industries 164;
Total Number of Facilities 17,916;
Number of Occupations 119;
Total Number of Employees Exposed 165,980
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 69220;
Number of Industries 249;
Total Number of Facilities 40,765;
Number of Occupations 152;
Total Number of Employees Exposed 557,740;
Total Number of Female Employees Exposed 110,040


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate, agricultural chemical, pesticide, food and feed additive
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
POASAD Proceedings of the Oklahoma Academy of Science. (Oklahoma Academy of Science, c/o Executive Secretary-Treasurer, Southwestern Oklahoma State Univ., Weatherford, OK 73096) V.1- 1910/1920-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SOVEA7 Southwestern Veterinarian. (College of Veterinary Medicine, Texas A & M Univ., College Station, TX 77843) V.1- 1948-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as a chemical intermediate, agricultural chemical, pesticide, food and feed additive

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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