The Registry of Toxic Effects of Chemical Substances

Sodium sulfate (2:1)

RTECS #: WE1650000

CAS #: 7757-82-6

UPDATE: August 2003 MW: 142.04 MF: O4S•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Dibasic sodium sulfate
  2. Disodium monosulfate
  3. Disodium sulfate
  4. Salt cake
  5. Bisodium sulfate
  6. Kemol
  1. Natriumsulfat (German)
  2. Sodium sulfate anhydrous
  3. Sodium sulphate
  4. Sulfuric acid, disodium salt
  5. Thenardite


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 14 gm/kg (8-12 day pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects TCMUD8 6,361,1986
parenteral
mouse 		lowest published toxic dose: 60 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JPMSAE 62,1626,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 806 mg/kg/26 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		IVIVE4 1,39,1987


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lowest published lethal dose: 1,220 mg/kg N/R CLDND*
intravenous
rabbit 		lethal dose (50 percent kill): 1,220 mg/kg N/R NIIRDN -,1257,1990
oral
mouse 		lethal dose (50 percent kill): 5,989 mg/kg N/R SKEZAP 4,15,1963


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,320,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81663;
Number of Industries 311;
Total Number of Facilities 94,825;
Number of Occupations 160;
Total Number of Employees Exposed 866,411
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81663;
Number of Industries 311;
Total Number of Facilities 68,367;
Number of Occupations 202;
Total Number of Employees Exposed 1,332,131;
Total Number of Female Employees Exposed 543,877


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a precipitating agent in the manufacture of SILVER emulsions, an analytical reagent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8786
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IVIVE4 In Vivo. (POB 51359, Kiffisia, GR-145 10, Greece) V.1- 1987-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-

Used as a precipitating agent in the manufacture of SILVER emulsions, an analytical reagent

Top 50 chemical production: 1.34 billions lbs in 1992, 1.59 billions in 1991

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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