The Registry of Toxic Effects of Chemical Substances

Stannane, hydroxytriphenyl -

RTECS #: WH8575000

CAS #: 76-87-9

UPDATE: May 2004 MW: 367.03 MF: C18H16OSn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Dowco 186
  2. Du - Ter
  3. Du - Ter W - 50
  4. ENT 28009
  5. Erithane
  6. Fenolovo
  7. Fentin hydroxide
  8. Fintine hydroxyde (French)
  9. Fintin hydroxid (German)
  10. Fintin hydroxyde (Dutch)
  11. Fintin idrossido (Italian)
  12. Flo - Tin 4L
  13. Hydroxyde de triphenyl - etain (French)
  14. Hydroxytriphenylstannane
  15. Hydroxytriphenyltin
  16. Idrossido di stagno trifenile (Italian)
  17. OMS 1017
  1. Phenostat - H
  2. Haitin
  3. K 19
  4. NCI - C00260
  5. TPTH
  6. Tptoh
  7. Sunitron H
  8. Suzu H
  9. Tin, hydroxytriphenyl -
  10. Trifenylstanniumhydroxid (Czech)
  11. Trifenyl - tinhydroxyde (Dutch)
  12. Triphenylstannium hydroxide
  13. Triphenyltin hydroxide
  14. Triphenyltin oxide
  15. Triphenyl - zinnhydroxid (German)
  16. Vancide KS


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
guinea pig 		1,00%/2S rinse severe TXAPA9 14,628,1969
eye
rabbit 		10 mg severe CTOXAO 13,281,1978
skin
human 		0.5 %/48 hour CODEDG 17,212,1987


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
micronucleus test hamster ovary 150 µg/L MUREAV 444,167,1999
micronucleus test oral
mouse 		2,500 µg/kg MUREAV 444,167,1999
micronucleus test intraperitoneal
mouse 		2,500 µg/kg MUREAV 444,167,1999
morphological transform rat embryo 19 ng/plate JJATDK 1,190,1981
other mutation test systems hamster ovary 60 µg/L MUREAV 300,5,1993
sister chromatid exchange hamster ovary 25 µg/L MUREAV 444,167,1999


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 105 mg/kg (8-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) CTOXAO 13,281,1978
oral
rat 		lowest published toxic dose: 140 mg/kg (1-7 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) CTOXAO 13,281,1978
oral
rat 		lowest published toxic dose: 140 mg/kg (1-7 day pregnant) Reproductive: Effects on fertility: Other measures of fertility TOANDB 3,281,1979
oral
rat 		lowest published toxic dose: 130 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TJADAB 42,651,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 60 mg/m3 N/R HBPTO* 2,1216,2001
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 3,740 µg/kg N/R BJIMAG 23,222,1966
intraperitoneal
mouse 		lowest published lethal dose: 8,500 µg/kg N/R TXAPA9 23,288,1972
intraperitoneal
rat 		lowest published lethal dose: 100 mg/kg N/R NCNSA6 5,46,1953
intravenous
rabbit 		lowest published lethal dose: 25 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		CTOXAO 13,281,1978
oral
guinea pig 		lethal dose (50 percent kill): 27 mg/kg N/R HBPTO* 2,1216,2001
oral
mouse 		lethal dose (50 percent kill): 209 mg/kg N/R YKYUA6 30,505,1979
oral
rat 		lethal dose (50 percent kill): 46 mg/kg N/R NCILB* NCI-E-C-72-3252,1973
skin
rat 		lethal dose (50 percent kill): 1,600 mg/kg N/R HBPTO* 2,1216,2001
skin
rabbit 		lethal dose (50 percent kill): 1,600 mg/kg N/R HBPTO* 2,1216,2001
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 500 mg/kg N/R 30ZDA9 -,302,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 2 mg/m3/13 week- continuous Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Luekopenia 		HBPTO* 2,1221,2001
inhalation
rat 		lowest published toxic concentration: 2 mg/m3/13 week- continuous Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Luekopenia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		HBPTO* 2,1221,2001
oral
dog 		lowest published toxic dose: 92,500 µg/kg/14 week- continuous Behavioral: Somnolence (general depressed activity) RREVAH 79,1,1981
oral
domestic animal 		lowest published toxic dose: 42 mg/kg/70 day- continuous Endocrine: Other changes

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		HBPTO* 2,1221,2001
oral
guinea pig 		lowest published toxic dose: 13,500 µg/kg/90 day- continuous Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count 		FCTXAV 4,35,1966
oral
mouse 		lowest published toxic dose: 182.2 mg/kg/2 year- continuous Blood: Luekopenia HBPTO* 2,1221,2001
oral
rat 		lowest published toxic dose: 1,350 mg/kg/90 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field CTOXAO 13,281,1978
oral
rat 		lowest published toxic dose: 20 mg/kg/20 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		RREVAH 79,1,1981
oral
rat 		lowest published toxic dose: 500 mg/kg/25 day- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) HBPTO* 2,1222,2001
oral
rabbit 		lowest published toxic dose: 31.5 mg/kg/70 day- continuous Endocrine: Other changes

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		HBPTO* 2,1221,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(Sn)/m3;short term exposure limit 0.2 mg/m3 (skin) DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,1999
TOXICOLOGY REVIEW
EQSFAP 4,80,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,151,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg(Sn)/m3 DTLVS* 3,258,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Sn)/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg(Sn)/m3, Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(Sn)/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg(Sn)/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.3 mg(Se)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg(Sn)/m3, VLE 0.2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 mg(Sn)/m3, Skin, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 0.1 mg(Sn)/m3, Skin, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Sn)/m3, KZG- week 0.2 mg(Sn)/m3, Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as a human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as a human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ORGANOTIN COMPOUND-air 10 hour time-weighted average 0.1 mg(Sn)/m3 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in vinyl products to protect against mildew growth and stiffening by bacteria and fungi
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-139,1978


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSFAP Environmental Quality and Safety. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1972-76. Discontinued.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOANDB Toxicology Annual. (New York, NY) 1974/75-79. Discontinued.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used in vinyl products to protect against mildew growth and stiffening by bacteria and fungi

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Organometallic
   Mutagen
   Reproductive Effector
   Hormone
   Primary Irritant

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