The Registry of Toxic Effects of Chemical Substances

Styrene, alpha - methyl -

RTECS #: WL5075300

CAS #: 98-83-9

UPDATE: November 2004 MW: 118.19 MF: C9H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Methyl - 1 - phenylethylene
  2. 2 - Phenylpropene
  3. 2 - Phenylpropylene
  4. Benzene, (1 - methylethenyl) -
  5. Isopropenil - benzolo (Italian)
  6. Isopropenyl - benzeen (Dutch)
  7. Isopropenyl - benzol (German)
  8. alpha - Methyl styrene
  9. alpha - Methyl styrene (ACGIH:OSHA)
  1. alpha - Methyl styrene, fume
  2. alpha - Methyl - styrol (German)
  3. alpha - Methylstyreen (Dutch)
  4. alpha - Methylstyrene
  5. alpha - Metil - stirolo (Italian)
  6. as - Methylphenylethylene
  7. beta - Phenylpropene
  8. beta - Phenylpropylene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		91 mg mild AMIHAB 14,387,1956
skin
rabbit 		1,00% moderate AMIHAB 14,387,1956


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange human lymphocyte 330 µmol/L MUREAV 116,379,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 3,000 ppm N/R 28ZRAQ -,131,1960
inhalation
human 		lowest published toxic concentration: 600 ppm Olfaction: Other olfaction effects

Eye: Other eye effects 		AMIHAB 14,387,1956
inhalation
human 		lowest published toxic concentration: 600 ppm Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVGH* -,203,1990
inhalation
rat 		lowest published lethal concentration: 3,000 ppm N/R 28ZRAQ -,131,1960
oral
mouse 		lethal dose (50 percent kill): 4,500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Body temperature decrease 		GISAAA 28(12),14,1963
oral
mouse 		lethal dose (50 percent kill): 50,000 mg/kg N/R VCVGH* -,203,1990
oral
rat 		lethal dose (50 percent kill): 4,900 mg/kg N/R AMIHAB 14,387,1956
skin
rabbit 		lowest published lethal dose: 16 mL/kg N/R UCDS** 5/24/1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 3,000 ppm/7 hour/24 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGH* -,203,1990
inhalation
rat 		lowest published toxic concentration: 50 mg/m3/6 hour/22 week- intermittent Behavioral: Muscle contraction or spasticity

Vascular: BP lowering not characterized in autonomic section

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GISAAA 28(12),14,1963
inhalation
rat 		lowest published toxic concentration: 5 mg/m3/24 hour/13 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes 		GISAAA 31(2),3,1966
inhalation
rat 		lowest published toxic concentration: 3,000 ppm/7 hour/24 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGH* -,203,1990
oral
mouse 		lowest published toxic dose: 15 gm/kg/30 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain GISAAA 29(4),24,1964
oral
rat 		lowest published toxic dose: 15 gm/kg/30 day- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Changes in leukocyte (WBC) count 		GTPZAB 23(6),38,1979
oral
rat 		lowest published toxic dose: 1,400 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGH* -,203,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm ;short term exposure limit 100 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 100 ppm DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 100 ppm (480 mg/m3) DTLVS* 3,170,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 100 ppm (480 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 100 ppm (480 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 100 ppm (480 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 100 ppm (480 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (240 mg/m3), short term exposure limit 100 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 100 ppm (480 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (242 mg/m3), short term exposure limit 100 ppm (484 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (480 mg/m3), short term exposure limit 150 ppm (720 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 100 ppm (480 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 50 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 240 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 100 ppm (480 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 100 ppm (491 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 100 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 100 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO alpha-METHYLSTYRENE-air 10 hour time-weighted average 50 ppm;
short term exposure limit 100 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1533;
Number of Industries 20;
Total Number of Facilities 1,933;
Number of Occupations 32;
Total Number of Employees Exposed 24,824
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1533;
Number of Industries 3;
Total Number of Facilities 354;
Number of Occupations 4;
Total Number of Employees Exposed 3,214


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as additive, plasticizer and copolymer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9275
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501
NTP Carcinogenesis studies; on test (prechronic studies), October 2000


REFERENCES:

CODEN
REFERENCE
28ZRAQ "Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde, H., New York, Elsevier, 1960
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as additive, plasticizer and copolymer

NIOSH PROFILE (ARENES), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

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