The Registry of Toxic Effects of Chemical Substances

Succinonitrile

RTECS #: WN3850000

CAS #: 110-61-2

UPDATE: October 1997 MW: 80.10 MF: C4H4N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. s - Dicyanoethane
  2. Dinile
  3. Ethylene cyanide
  4. Ethylene dicyanide
  5. Succinic acid dinitrile
  6. Butanedinitrile
  7. Deprelin
  1. Ethane, 1,2 - dicyano -
  2. Succinic dinitrile
  3. Succinodinitrile
  4. Suxil
  5. Sukcinonitril (Czech)
  6. USAF A - 9442


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
hamster 		lowest published toxic dose: 365 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system 		FAATDF 3,41,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 730 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Acute pulmonary edema 		NTIS** OTS0570875
intraperitoneal
mouse 		lethal dose (50 percent kill): 63,110 µg/kg Kidney, Ureter, and Bladder: Other changes in urine composition BCPCA6 27,1135,1978
oral
mouse 		lethal dose (50 percent kill): 129 mg/kg N/R ARTODN 57,88,1985
oral
rat 		lethal dose (50 percent kill): 450 mg/kg N/R 38MKAJ 2C,4879,1982
subcutaneous
dog 		lowest published lethal dose: 150 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting 		AIPTAK 3,77,1897
subcutaneous
frog 		lowest published lethal dose: 1 gm/kg N/R AIPTAK 3,77,1897
subcutaneous
pigeon 		lowest published lethal dose: 2,200 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting 		AIPTAK 3,77,1897
subcutaneous
rabbit 		lowest published lethal dose: 36 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change AIPTAK 3,77,1897


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SUCCINONITRILE-air 10 hour time-weighted average 6 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5846;
Number of Industries 1;
Total Number of Facilities 44;
Number of Occupations 3;
Total Number of Employees Exposed 1,440


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antidepressive agent in some European countries
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as an antidepressive agent in some European countries

RTECS Compound Description:
   Reproductive Effector

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