The Registry of Toxic Effects of Chemical Substances

Sulfuric acid, monododecyl ester, sodium salt

RTECS #: WT1050000

CAS #: 151-21-3

UPDATE: May 2005 MW: 288.42 MF: C12H25O4S•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. AI3 - 00356
  2. Akyposal SDS
  3. Aquarex ME
  4. Aquarex methyl
  5. Avirol 101
  6. Avirol 118 conc
  7. Conco sulfate WA
  8. Conco sulfate WA - 1200
  9. Conco sulfate WA - 1245
  10. Conco Sulfate WAG
  11. Sipon WD
  12. SLS
  13. Sodium dodecyl sulfate
  14. Sodium n - dodecyl sulfate
  15. Sodium dodecyl sulphate
  16. Sodium lauryl sulfate
  17. Sodium lauryl sulphate
  18. Sodium monododecyl sulfate
  19. Sodium monolauryl sulfate
  20. Solsol needles
  21. Conco Sulfate WAN
  22. Standapol 112 conc
  23. Standapol WA - AC
  24. Standapol WAQ
  25. Standapol WAQ Special
  26. Standapol WAS 100
  27. Steinapol NLS 90
  28. Stepanol ME
  29. Stepanol ME Dry
  30. Stepanol ME Dry AW
  31. Stepanol methyl
  32. Conco Sulfate WAS
  33. Stepanol methyl dry AW
  34. Stepanol T 28
  35. Stepanol WA
  36. Stepanol WA - 100
  37. Stepanol WAC
  38. Stepanol WA paste
  39. Stepanol WAQ
  40. Sterling WA paste
  41. Sterling WAQ - CH
  42. Sterling waq - cosmetic
  43. Conco sulfate WN
  44. Sulfopon WA 1
  45. Sulfopon WA 2
  46. Sulfopon WA 3
  47. Sulfopon WA 1 special
  48. Sulfotex WA
  49. Sulfotex WALA
  50. Swascol 3L
  51. Swascol 4L
  52. Swascol 1P
  53. Syntapon
  54. CP 75424
  55. Trepenol WA
  56. Syntapon L
  57. Syntapon L pasta (Czech)
  58. Tarapon K 12
  59. Texapon DL conc.
  60. Texapon K12
  61. Texapon K - 1296
  62. Texapon L 100
  63. Texapon V HC
  64. Texapon V HC powder
  65. Finasol osr (sub 2)
  66. Texapon ZHC
  67. Texapon Z high conc. needles
  68. TVM 474
  69. Ultra sulfate SL - 1
  70. WAQE
  71. Witcolate A
  72. Witcolate A powder
  73. Witcolate C
  74. Incronol SLS
  75. Odoripon AL 95
  76. Orvus WA paste
  77. P and G emulsifier 104
  78. Sulfetal L 95
  79. Berol 452
  1. Carsonol SLS
  2. Carsonol SLS Paste B
  3. Carsonol SLS Special
  4. Cycloryl 21
  5. Cycloryl 31
  6. Cycloryl 580
  7. Cycloryl 585N
  8. Dehydag sulfate GL emulsion
  9. Dehydag sulphate GL emulsion
  10. Detergent 66
  11. Dodecyl alcohol, hydrogen sulfate, sodium salt
  12. Dodecyl sodium sulfate
  13. Dodecyl sulfate sodium
  14. n - Dodecyl sulfate sodium
  15. Dodecyl sulfate, sodium salt
  16. Dreft
  17. Duponal
  18. Duponal WAQE
  19. Duponol
  20. Duponol C
  21. Duponol ME
  22. Duponol methyl
  23. Duponol QX
  24. Duponol WA
  25. Duponol WA Dry
  26. Duponol WAQ
  27. Duponol WAQA
  28. Duponol WAQE
  29. Duponol WAQM
  30. EMAL O
  31. EMAL 10
  32. Emersal 6400
  33. Empicol LPZ
  34. Empicol LS 30
  35. Empicol LX 28
  36. Emulsifier No. 104
  37. Gardinol
  38. Hexamol SLS
  39. Irium
  40. Jordanol SL - 300
  41. Lanette wax - S
  42. Laurylsiran sodny (Czech)
  43. Lauryl sodium sulfate
  44. Lauryl sulfate, sodium salt
  45. Maprofix 563
  46. Maprofix LK
  47. Maprofix NEU
  48. Maprofix WAC
  49. Maprofix wac - LA
  50. Melanol CL
  51. Melanol CL 30
  52. Monododecyl sodium sulfate
  53. Monogen Y 100
  54. Montopol LA paste
  55. NCI - C50191
  56. Neutrazyme
  57. Nikkol SLS
  58. Perlandrol L
  59. Product No. 75
  60. Product No. 161
  61. Quolac EX - UB
  62. Rewopol NLS 30
  63. Richonol A
  64. Richonol AF
  65. Richonol C
  66. SDS
  67. Sinnopon LS 95
  68. Sinnopon LS 100
  69. Sintapon L
  70. Sipex OP
  71. Sipex SB
  72. Sipex SD
  73. Sipex SP
  74. Sipex UB
  75. Sipon LS
  76. Sipon LS 100
  77. Sipon LSB
  78. Sipon PD


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/24 hour moderate 28ZPAK -,305,1972
eye
rabbit 		250 µg mild AROPAW 34,99,1945
eye
rabbit 		2 mg mild DCTODJ 1,305,1978
eye
rabbit 		10 mg moderate TXAPA9 55,501,1980
skin
dog 		25 mg/24 hour mild JSCCA5 23,371,1972
skin
guinea pig 		25 mg/24 hour mild JSCCA5 23,371,1972
skin
human 		250 mg/24 hour mild TXAPA9 31,481,1975
skin
human 		25 mg/24 hour mild JSCCA5 23,371,1972
skin
human 		0.6%/24 hour mild JIDEAE 10,159,1995
skin
human 		0.1%/24 hour moderate JIDEAE 76,341,1996
skin
human 		0.5%/23 hour JIDEAE 76,450,1996
skin
human 		0.5%/47 hour mild JIDEAE 39,240,1998
skin
human 		10%/22 hour mild JIDEAE 11,474,1984
skin
human 		2%/18 hour mild JIDEAE 92,693,1975
skin
human 		3%/48 hour moderate JIDEAE 20,335,1989
skin
human 		1%/48 hour CODEDG 42,111,2000
skin
human 		0.5%/24 hour JAADDB 30,944,1994
skin
mouse 		25 mg/24 hour moderate JSCCA5 23,371,1972
skin
pig 		25 mg/24 hour mild JSCCA5 23,371,1972
skin
rat 		10%/1 hour TOXID9 72,379,2003
skin
rabbit 		50 mg/24 hour severe BIOFX* 23-3/1971
skin
rabbit 		25 mg/24 hour moderate JSCCA5 23,371,1972
skin
rabbit 		250 mg/24 hour moderate TXAPA9 31,481,1975
skin
rabbit 		10 mg/24 hour moderate DCTODJ 1,305,1978
skin
rabbit 		50 mg/24 hour mild TXAPA9 21,369,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage rat liver 243 µmol/L EMMUEG 24,181,1994
DNA inhibition guinea pig kidney 60 µmol/L FCTXAV 14,431,1976
DNA inhibition human lymphocyte 100 mg/L BECTA6 28,504,1982
DNA repair Escherichia coli 12,500 nL/well MUREAV 158,19,1985
mutation in microorganisms other microorganisms 200 mg/L (-enzymatic activation step) JDREAF 55,266,1976
mutation in microorganisms Saccharomyes cerevisiae 3,500 µmol/L (-enzymatic activation step) JOBAAY 115,461,1973
sex chromosome loss and nondisjunction Aspergillus nidulans 900 ppm MUREAV 142,179,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 480 mg/kg (6-13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TRENAF 27,113,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >3,900 mg/m3/1 hour N/R BIOFX* 23-3/1971
intraperitoneal
mouse 		lethal dose (50 percent kill): 250 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Vascular: Regional or general arteriolar or venous dilation 		JAPMA8 42,283,1953
intraperitoneal
rat 		lethal dose (50 percent kill): 210 mg/kg N/R PSTGAW 3,1,1945
intravenous
mouse 		lethal dose (50 percent kill): 118 mg/kg N/R JPMSAE 52,803,1963
intravenous
rat 		lethal dose (50 percent kill): 118 mg/kg N/R JPMSAE 52,803,1963
oral
rat 		lethal dose (50 percent kill): 1,288 mg/kg N/R FCTXAV 5,763,1967
skin
human 		lowest published toxic dose: 0.14 mg/kg/24 hour Skin: After topical application: Primary irritation IJCMDW 22,73,2000
skin
mouse 		lowest published toxic dose: 200 mg/kg Skin: After topical application: Cutaneous sensitization (experimental)

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXAPA9 182,126,2002
skin
rabbit 		lowest published lethal dose: 10 gm/kg Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea 		BIOFX* 23-3/1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 75 mg/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JJATDK 7,213,1987
oral
rat 		lowest published toxic dose: 22,750 mg/kg/13 week- continuous Liver: Changes in liver weight FCTXAV 5,763,1967
oral
rat 		lowest published toxic dose: 840 mg/kg/28 day- continuous Endocrine: Changes in adrenal weight BIOFX* 23-3/1971
skin
human 		lowest published toxic dose: 0.45 mg/kg/3 week- intermittent Skin: After topical application: Primary irritation CODEDG 42,264,2000
skin
mouse 		lowest published toxic dose: 150 mg/kg/3 day- intermittent Immunological Including Allergic: Decrease in cellular immune response ETOPFR 17,95,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ARTODN 32,245,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,323,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81990;
Number of Industries 167;
Total Number of Facilities 32,028;
Number of Occupations 113;
Total Number of Employees Exposed 388,848
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81990;
Number of Industries 232;
Total Number of Facilities 46,312;
Number of Occupations 170;
Total Number of Employees Exposed 886,968;
Total Number of Female Employees Exposed 415,360


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an oil dispersant, and as a cosmetic and perfume ingredient
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8800
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IJCMDW International Journal of Cosmetic Science. (Blackwell Scientific Pub. Inc., 52 Beacon St., Boston, MA 02108) V.1- 1979-
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1916-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PSTGAW Proceedings of the Scientific Section of the Toilet Goods Association. (Washington, DC) No.1-48, 1944-67. Discontinued.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an oil dispersant, and as a cosmetic and perfume ingredient

FDA-over the counter drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

ALT CAS #: 51222-39-0
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