The Registry of Toxic Effects of Chemical Substances

Talc (powder) , containing no asbestos fibers

RTECS #: WW2710000

CAS #: 14807-96-6

UPDATE: November 2004 MW: 96.33 MF: H203Si•3/4Mg


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Agalite
  2. Asbestine
  3. B 13
  4. B 13 (mineral)
  5. B 13 (mineral)
  6. B 9
  7. B 9 (talc)
  8. Beaver White 200
  9. Beaver White 325
  10. CP 10 - 40
  11. CP 38 - 33
  12. CT 8 (mineral)
  13. Cimflex 606
  14. Circron MP
  15. Crown Talc W 83
  16. Crown Talc Z
  17. Crystalite CRS 6002
  18. Cubic Master
  19. Desertalc 57
  20. EX - IT
  21. Emtal 500
  22. Emtal 549
  23. Emtal 596
  24. Emtal 599
  25. FW - XO
  26. Fibrene C 400
  27. Finntalc C10
  28. Finntalc M05
  29. Finntalc M15
  30. Finntalc P40
  31. Finntalc PF
  32. IT Extra
  33. LMR 100
  34. MP 12 - 50
  35. MP 25 - 38
  36. MP 40 - 27
  1. MP 45 - 26
  2. MST
  3. Micro Ace K1
  4. Micro Ace L1
  5. Micron White 5000A
  6. Micron White 5000P
  7. Micron White 5000S
  8. Microtalco IT Extra
  9. Mistron 139
  10. Mistron 2SC
  11. Mistron RCS
  12. Mistron Star
  13. Mistron frost P
  14. Mistron super frost
  15. Mistron vapor
  16. Mussolinite
  17. Nytal 200
  18. Nytal 400
  19. P 3
  20. P 3 (Mineral)
  21. PK - C
  22. PK - N
  23. Polytal 4641
  24. Polytal 4725
  25. Silicate: talc, containing no asbestos (OSHA)
  26. Steawhite
  27. Supreme
  28. Supreme dense
  29. TY 80
  30. Talc
  31. Talc (ACGIH)
  32. Talc, containing no asbestos fibers
  33. Talcan PK - P
  34. Talcron CP 44 - 31
  35. Talcum


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		300 µg/3 day- intermittent mild 85DKA8 -,127,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis inhalation
mouse 		0.5 ppb EMMUEG 39,69,2002
cytogenetic analysis inhalation
rat 		0.5 ppb EMMUEG 39,69,2002
specific locus test inhalation
mouse 		0.5 ppb EMMUEG 39,69,2002
specific locus test inhalation
rat 		0.5 ppb EMMUEG 39,69,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 18 mg/m3/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Endocrine: Tumors 		NTPTR* NTP-TR-421,1993
inhalation
rat 		toxic concentration (other than lowest) : 11 mg/m3/1 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		43GRAK -,389,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 20,400 µg/m3/6 hour/26 day- intermittent Lung, Thorax, or Respiration: Other changes ENVRAL 49,233,1989
inhalation
rat 		lowest published toxic concentration: 17 mg/m3/6 hour/26 day- intermittent Lung, Thorax, or Respiration: Other changes ENVRAL 49,233,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg/m3 (E,R) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 42,185,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 42,185,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,349,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 20 million particles per cubic foot, respirable dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 20 million particles per cubic foot, respirable dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 20 million particles per cubic foot CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 20 million particles per cubic foot, respirable dust CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg/m3, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 2 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 mg/m3 (resp. dust), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 mg/m3,respirable dust, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TALC (containing no asbestos)-air 10 hour 2 mg/m3 NIOSH* PHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 71055;
Number of Industries 243;
Total Number of Facilities 38,349;
Number of Occupations 149;
Total Number of Employees Exposed 527,353
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9093;
Number of Industries 2;
Total Number of Facilities 273;
Number of Occupations 2;
Total Number of Employees Exposed 4,245;
Total Number of Female Employees Exposed 590
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 71055;
Number of Industries 313;
Total Number of Facilities 82,650;
Number of Occupations 192;
Total Number of Employees Exposed 1,367,384;
Total Number of Female Employees Exposed 348,973


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:rat
NCI Carcinogenesis Studies (inhal);no evidence:mouse


REFERENCES:

CODEN
REFERENCE
43GRAK "Dusts and Disease, Proceedings of the Conference on Occupational Exposures to Fibrous and Particulate Dust and Their Extension into the Environment, 1977," Lemen, R., and J.M. Dement, eds., Park Forest South, IL, Pathotox Pub., 1979
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

NIOSH PROFILE (TALC), SRC, 10/77

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Natural Product
   Primary Irritant

ALT CAS #: 11119-41-8
ALT CAS #: 12420-12-1
ALT CAS #: 37232-12-5
ALT CAS #: 99638-63-8
ALT CAS #: 110540-41-5
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