The Registry of Toxic Effects of Chemical Substances

2,5,8,11 - Tetraoxadodecane

RTECS #: XF0665000

CAS #: 112-49-2

UPDATE: August 2003 MW: 178.26 MF: C8H18O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Ansul ether 161
  2. Glyme 4
  1. Triethylene glycol dimethyl ether
  2. Triglyme


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		NTIS** PB86-103215
oral
mouse 		lowest published toxic dose: 5 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 31,53A,1985
oral
mouse 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina NTIS** PB86-103215
oral
mouse 		lowest published toxic dose: 28 gm/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) TCMUD8 7,29,1987
oral
mouse 		lowest published toxic dose: 28,000 mg/kg (7-14 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) EVHPAZ 57,141,1984
oral
mouse 		lowest published toxic dose: 6.1 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		NTIS** #PB85150456/AS
oral
mouse 		lowest published toxic dose: 3 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB85150456/AS
oral
mouse 		lowest published toxic dose: 25,872 mg/kg (21 week prior to copulation) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Sex ratio

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** #PB85150456/AS
oral
mouse 		lowest published toxic dose: 5,000 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** #PB86-103215
oral
mouse 		lowest published toxic dose: 2,500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB86-103215
oral
rabbit 		lowest published toxic dose: 3,500 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** PB87-181657
oral
rabbit 		lowest published toxic dose: 3,500 mg/kg (6-19 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** PB87-181657
oral
rabbit 		lowest published toxic dose: 3,325 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		FAATDF 19,238,1992
oral
rabbit 		lowest published toxic dose: 3,500 mg/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB87-181657
oral
rabbit 		lowest published toxic dose: 2,450 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** #PB87-181657
oral
rabbit 		lowest published toxic dose: 2,450 mg/kg (6-19 day pregnant) Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system 		NTIS** #PB87-181657
oral
rabbit 		lowest published toxic dose: 2,450 mg/kg (6-19 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system NTIS** #PB87-181657


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 4,456 mg/kg/10 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) NTIS** OTS0543414


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 28,000 mg/kg/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field EVHPAZ 57,141,1984
oral
mouse 		lowest published toxic dose: 2,450 mg/kg/14 day- continuous Behavioral: Food intake (animal)

Behavioral: Fluid intake 		NTIS** #PB85150456/AS
oral
mouse 		lowest published toxic dose: 25,872 mg/kg/21 week- continuous Liver: Changes in liver weight NTIS** #PB85150456/AS
oral
mouse 		lowest published toxic dose: 25,872 mg/kg/21 week- continuous Endocrine: Changes in pituitary weight NTIS** #PB85150456/AS
oral
mouse 		lowest published toxic dose: 5,000 mg/kg/10 day- intermittent Liver: Changes in liver weight NTIS** #PB86-103215
oral
mouse 		lowest published toxic dose: 2,500 mg/kg/10 day- intermittent Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB86-103215
oral
rabbit 		lowest published toxic dose: 3,500 mg/kg/14 day- intermittent Liver: Changes in liver weight NTIS** #PB87-181657
oral
rabbit 		lowest published toxic dose: 2,450 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB87-181657


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
FAATDF 13,747,1989


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: E0064;
Number of Industries 1;
Total Number of Facilities 27;
Number of Occupations 1;
Total Number of Employees Exposed 270


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial solvent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

Used as an industrial solvent

RTECS Compound Description:
   Reproductive Effector

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