The Registry of Toxic Effects of Chemical Substances

Thiocyanic acid, sodium salt

RTECS #: XL2275000

CAS #: 540-72-7

UPDATE: February 2003 MW: 81.07 MF: CNS•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Sodium thiocyanate
  2. Sodium thiocyanide
  3. Thiocyanate sodium
  4. Thiocyanic acid, sodium salt, ground
  5. USAF EK - T - 434
  6. Haimased
  7. Natriumrhodanid (German)
  1. Scyan
  2. Sodium isothiocyanate
  3. Sodium rhodanate
  4. Sodium rhodanide
  5. Sodium sulfocyanate
  6. Sodium sulfocyanide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
guinea pig 		lowest published lethal dose: 500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity 		AEPPAE 169,429,1933
intraperitoneal
mouse 		lethal dose (50 percent kill): 500 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		JJPAAZ 3,99,1954
intraperitoneal
rat 		lethal dose (50 percent kill): 540 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		JPETAB 96,416,1949
intratracheal
rat 		lethal dose (50 percent kill): 232 mg/kg N/R 85GMAT -,106,1982
intravenous
dog 		lowest published lethal dose: 100 mg/kg Gastrointestinal: Nausea or vomiting AEPPAE 169,429,1933
intravenous
mouse 		lethal dose (50 percent kill): 484 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		JAPMA8 29,152,1940
intravenous
rabbit 		lowest published lethal dose: 100 mg/kg N/R AEPPAE 169,429,1933
oral
domestic animal 		lethal dose (50 percent kill): 520 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany 		VCVN1* -,353,1988
oral
guinea pig 		lowest published lethal dose: 600 mg/kg N/R JAPMA8 29,152,1940
oral
mouse 		lethal dose (50 percent kill): 362 mg/kg N/R 85GMAT -,106,1982
oral
mouse 		lethal dose (50 percent kill): 360 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany 		VCVN1* -,353,1988
oral
mouse 		lethal dose (50 percent kill): 809 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany 		VCVN1* -,353,1988
oral
rat 		lethal dose (50 percent kill): 764 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		JAPMA8 29,152,1940
oral
rat 		lethal dose (50 percent kill): 1,180 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany 		VCVN1* -,353,1988
oral
rat 		lethal dose (50 percent kill): 232 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany 		VCVN1* -,353,1988
oral
rat 		lethal dose (50 percent kill): 837 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany 		VCVN1* -,353,1988
oral
rabbit 		lowest published lethal dose: 750 mg/kg N/R AEPPAE 169,429,1933
subcutaneous
guinea pig 		lowest published lethal dose: 500 mg/kg N/R JAPMA8 29,152,1940
subcutaneous
mouse 		lowest published lethal dose: 400 mg/kg N/R JAPMA8 29,152,1940
subcutaneous
rabbit 		lowest published lethal dose: 200 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Food intake (animal) 		AEPPAE 152,250,1930


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 612 mg/kg/23 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JAPMA8 29,152,1940
oral
mouse 		lowest published toxic dose: 490 mg/kg/7 week- continuous Endocrine: Changes in thyroid weight ECJPAE 32,635,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84443;
Number of Industries 28;
Total Number of Facilities 5,091;
Number of Occupations 31;
Total Number of Employees Exposed 28,357
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84443;
Number of Industries 26;
Total Number of Facilities 1,116;
Number of Occupations 25;
Total Number of Employees Exposed 28,328;
Total Number of Female Employees Exposed 6,415


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical, pharmaceutical and veterinary drug
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as an industrial chemical, pharmaceutical and veterinary drug

RTECS Compound Description:
   Agricultural Chemical
   Drug

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