The Registry of Toxic Effects of Chemical Substances

Toluene, o - chloro -

RTECS #: XS9000000

CAS #: 95-49-8

UPDATE: November 2004 MW: 126.59 MF: C7H7Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Benzene, 1 - chloro - 2 - methyl - (9CI)
  2. 1 - Chloro - 2 - methylbenzene
  3. 2 - Chloro - 1 - methylbenzene
  4. o - Chlorotoluene
  5. 2 - Chlorotoluene
  1. o - Chlorotoluene (ACGIH)
  2. Halso 99
  3. 1 - Methyl - 2 - chlorobenzene
  4. 2 - Methylchlorobenzene
  5. o - Tolyl chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 µL moderate NTIS** OTS0572387


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 4,400 ppm Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation 		85INA8 6,308,1991
inhalation
mouse 		lowest published lethal concentration: 4,400 ppm Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation 		85INA8 6,308,1991
inhalation
rat 		lowest published lethal concentration: 4,400 ppm Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation 		85INA8 6,308,1991
oral
mouse 		lethal dose (50 percent kill): 2,500 mg/kg Eye: Other eye effects

Behavioral: Tremor

Behavioral: Excitement 		GTPZAB 25(10),56,1981
oral
rat 		lethal dose (50 percent kill): 3,900 mg/kg Eye: Other eye effects

Behavioral: Tremor

Behavioral: Excitement 		GTPZAB 25(10),56,1981
unreported route
guinea pig 		lethal dose (50 percent kill): 3 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression 		GISAAA 46(2),67,1981
unreported route
mouse 		lethal dose (50 percent kill): 4,400 mg/kg N/R GISAAA 45(12),64,1980
unreported route
rat 		lethal dose (50 percent kill): 5,700 mg/kg N/R GISAAA 45(12),64,1980


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 11,400 mg/m3/6 hour/14 day- intermittent Behavioral: Food intake (animal)

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0537026
inhalation
rabbit 		lowest published toxic concentration: 16 gm/m3/6 hour/23 day- intermittent Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Urine volume increased

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0537026
oral
rat 		lowest published toxic dose: 35,910 mg/kg/9 week- intermittent Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed

Blood: Other changes 		GISAAA 46(2),67,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (250 mg/m3), short term exposure limit 75 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (250 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (259 mg/m3), short term exposure limit 75 ppm (388 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (285 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (260 mg/m3), short term exposure limit 75 ppm (390 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (250 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 250 mg/m3, Skin, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (250 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (264 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-CHLOROTOLUENE-air 10 hour time-weighted average 50 ppm;
short term exposure limit 75 ppm 		NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1254;
Number of Industries 2;
Total Number of Facilities 62;
Number of Occupations 8;
Total Number of Employees Exposed 11,617;
Total Number of Female Employees Exposed 963


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Primary Irritant

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