The Registry of Toxic Effects of Chemical Substances

Toluene, 2,6 - dinitro -

RTECS #: XT1925000

CAS #: 606-20-2

UPDATE: October 2002 MW: 182.15 MF: C7H6N2O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Benzene, 2 - methyl - 1,3 - dinitro - (9CI)
  2. 2,6 - Dinitrotoluene
  3. 2,6 - DNT
  1. RCRA waste number U106
  2. 1 - Methyl - 2,6 - dinitrobenzene
  3. 2 - Methyl - 1,3 - dinitrobenzene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour mild NTIS** AD-B011-150


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay mouse
Salmonella typhimurium 		75 mg/kg CALEDQ 52,13,1990
body fluid assay rat
Salmonella typhimurium 		75 mg/kg CALEDQ 52,13,1990
cytogenetic analysis oral
rat 		1,260 mg/kg/6 week- continuous NTIS** AD-A062-015
DNA adduct skin
mouse 		192 µmol/kg CRNGDP 5,231,1984
DNA adduct intraperitoneal
rat 		219 µg/kg MUREAV 301,79,1993
DNA adduct oral
rat 		10 mg/kg JTEHD6 11,555,1983
DNA damage rat liver 3 mmol/L SinJF# 26OCT1982
DNA inhibition intraperitoneal
rat 		20 mg/kg/8 week- intermittent CBTOE2 7,111,1991
unscheduled DNA synthesis rat other cell types 10 µmol/L CBTOE2 7,111,1991
unscheduled DNA synthesis oral
rat 		5 mg/kg CRNGDP 3,241,1982
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) DTESD7 2,249,1977
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) SAIGBL 29,34,1987
morphological transform oral
rat 		58,800 µg/kg/3 week- continuous CRNGDP 7,1797,1986
other mutation test systems oral
rat 		10 mg/kg JTEHD6 11,555,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 2,555 mg/kg/1 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		JJIND8 79,1313,1987
oral
rat 		toxic dose : 5,110 mg/kg/1 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		PAACA3 24,91,1983


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 240 mg/m3/6 hour Behavioral: General anesthetic

Lung, Thorax, or Respiration: Fibrosing alveolitis

Lung, Thorax, or Respiration: Changes in lung weight 		NTIS** OTS0533663
oral
mouse 		lethal dose (50 percent kill): 621 mg/kg Behavioral: Somnolence (general depressed activity) NTIS** AD-A080-146
oral
rat 		lethal dose (50 percent kill): 177 mg/kg N/R NTIS** PB214-270


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 9 gm/kg/90 day- continuous Blood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 37,116,1976
oral
mouse 		lowest published toxic dose: 27 gm/kg/90 day- continuous Blood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 37,116,1976
oral
rat 		lowest published toxic dose: 13,500 mg/kg/90 day- intermittent Blood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 37,116,1976


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 65,309,1996
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 65,309,1996
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 65,309,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - UNITED KINGDOM Carcinogen, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,6-DINITROTOLUENE-air Carcinogen;
10 hour time-weighted average 1.5 mg/m3 (Sk) 		NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/122004)
EPA GENETOX PROGRAM 1988, Inconclusive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #44


REFERENCES:

CODEN
REFERENCE
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTESD7 Developments in Toxicology and Environtal Science. (Elsevier Science, New York, NY) V.1-15, 1977-87. Discontinued
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

NIOSH PROFILE (NITROTOLUENES), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

 Click Here for Additional Information about RTECS