The Registry of Toxic Effects of Chemical Substances

m - Toluidine

RTECS #: XU2800000

CAS #: 108-44-1

UPDATE: November 2004 MW: 107.17 MF: C7H9N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 3 - Amino - 1 - methylbenzene
  2. 3 - Aminophenylmethane
  3. 3 - Aminotoluen (Czech)
  4. m - Aminotoluene
  5. 3 - Aminotoluene
  6. Aniline, 3 - methyl -
  7. Benzenamine, 3 - methyl - (9CI)
  8. m - Methylaniline
  1. 3 - Methylaniline
  2. m - Methylbenzenamine
  3. 3 - Methylbenzenamine
  4. m - Toluidin (Czech)
  5. m - Toluidine (ACGIH)
  6. 3 - Toluidine
  7. m - Tolylamine
  8. m - Toluidyna (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,459,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,459,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 116 mg/kg N/R AISFAR 1,284,1951
oral
wild bird 		lethal dose (50 percent kill): 242 mg/kg N/R AECTCV 12,355,1983
oral
cat 		lethal dose (50 percent kill): >50 mg/kg N/R NTIS** OTS0573041
oral
mouse 		lethal dose (50 percent kill): 740 mg/kg N/R GTPZAB 25(8),50,1981
oral
rat 		lethal dose (50 percent kill): 450 mg/kg N/R JPETAB 90,260,1947
oral
rabbit 		lethal dose (50 percent kill): 750 mg/kg N/R VINIT* #4035-77
skin
rabbit 		lethal dose (50 percent kill): 3,250 mg/kg N/R NTIS** OTS0573041


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 8,400 mg/kg/30 day- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VINIT* #4035-77


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (9 mg/m3), Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (8.8 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (9 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (9 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND time-weighted average 2 ppm (9 mg/m3), Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 9 mg/m3, Skin, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81889;
Number of Industries 3;
Total Number of Facilities 257;
Number of Occupations 3;
Total Number of Employees Exposed 2,876


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as dye intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #ID-73


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AISFAR Archivio Italiano di Scienze Farmacologiche. (Modena, Italy) V.1-11, 1932-42; Series 2: V.1-3, 1948-50; Series 3: V.1-15, 1951-65. Discontinued.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications.

Used as dye intermediate

NIOSH PROFILE (AMINES, PRIMARY AROMATIC), SRI, 2/77

RTECS Compound Description:
   Primary Irritant

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