The Registry of Toxic Effects of Chemical Substances

s - Triazine - 2,4,6 - triol

RTECS #: XZ1800000

CAS #: 108-80-5

UPDATE: August 2003 MW: 129.09 MF: C3H3N3O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. CP 4789
  2. Cyanuric acid
  3. Isocyanuric acid
  4. Kyselina kyanurova (Czech)
  5. Pseudocyanuric acid
  6. sym - Triazinetriol
  1. s - 2,4,6 - Triazinetriol
  2. s - Triazine - 2,4,6 (1H,3H,5H) - trione
  3. Tricyanic acid
  4. Trihydroxycyanidine
  5. 2,4,6 - Trihydroxy - 1,3,5 - triazine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 28ZPAK -,152,1972
eye
rabbit 		20 mg/24 hour rinse mild MONS** -,-,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 130 gm/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease 		VOONAW 16(1),82,1970
oral
rat 		lowest published toxic dose: 55 gm/kg/82 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors 		VOONAW 16(1),82,1970
oral
rat 		toxic dose : 60,750 mg/kg/81 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		AJHEAA 64,155,1974
subcutaneous
rat 		lowest published toxic dose: 27 gm/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease 		VOONAW 16(1),82,1970
subcutaneous
rat 		toxic dose : 36 gm/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		AJHEAA 64,155,1974
skin
mouse 		lowest published toxic dose: 2,400 mg/kg/1 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		AJHEAA 64,155,1974
skin
mouse 		toxic dose : 138 gm/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		VOONAW 16(1),82,1970


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): >500 mg/kg N/R GISAAA 27(12),13,1962
intravenous
rat 		lethal dose (50 percent kill): >100 mg/kg N/R GISAAA 27(12),13,1962
oral
mammal (species unspecified) 		lethal dose (50 percent kill): >5 gm/kg N/R YKYUA6 31,959,1980
oral
mouse 		lethal dose (50 percent kill): 3,400 mg/kg N/R ZKMAAX 25,345,1985
oral
rat 		lethal dose (50 percent kill): 7,700 mg/kg N/R ZKMAAX 25,345,1985
oral
rabbit 		lethal dose : >10 gm/kg N/R MONS** -,-,1972
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R NTIS** OTS0538650


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 5,460 mg/kg/26 week- intermittent Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GISAAA 27(12),13,1962


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,97,1998
Occupational Exposure Limit - POLAND MAC(time-weighted average) dust 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81788;
Number of Industries 4;
Total Number of Facilities 276;
Number of Occupations 2;
Total Number of Employees Exposed 10,365
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81788;
Number of Industries 3;
Total Number of Facilities 37;
Number of Occupations 5;
Total Number of Employees Exposed 2,933;
Total Number of Female Employees Exposed 1,003


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in stabilization of CHLORINE solutions in swimming pools
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9222
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Cyanuric acid, 5030


REFERENCES:

CODEN
REFERENCE
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
AJHEAA American Journal of Public Health. (American Public Health Assoc., 1015 15th St., NW, Washington, DC 20005) V.2-17, 1912-27; V.61- 1971-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MONS** Monsanto Co. Toxicity Information. (Monsanto Industrial Chemicals Co., Bancroft Bldg., Suite 204, 3411 Silverside Rd., Wilmington, DE 19810)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-
ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny. Journal of Experimental and Clinical Medicine. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1962-

Used in stabilization of CHLORINE solutions in swimming pools

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Primary Irritant

ALT CAS #: 504-19-8
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