The Registry of Toxic Effects of Chemical Substances

1H - 1,2,4 - Triazole, 1 - ( (4 - bromo - 2 - (2,4 - dichlorophenyl) tetrahydro - 2 - furanyl) methyl) -

RTECS #: XZ4130000

CAS #: 116255-48-2

UPDATE: September 2000 MW: 377.09 MF: C13H12BrCl2N3O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STATUS IN FEDERAL AGENCIES:
  5. REFERENCES:

SYNONYMS:

  1. Bromoconazole
  2. Bromuconazole
  3. 1 - ( (2RS,4RS,2RS,4SR) - 4 - Bromo - 2 - (2,4 - dichlorophenyl) tetrahydrofurfuryl) - 1H - 1,2,4 - triazole
  1. 1 - ( (4 - Bromo - 2 - (2,4 - dichlorophenyl) tetrahydro - 2 - furanyl) methyl) - 1H - 1,2,4 - triazole
  2. LC 860263
  3. LS 860263


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rabbit 		lethal concentration (50 percent kill): >5 gm/m3 N/R PEMNDP 9,1140,1991
oral
duck 		lethal dose (50 percent kill): >2,150 mg/kg N/R PEMNDP 9,1140,1991
oral
mouse 		lethal dose (50 percent kill): 1,151 mg/kg N/R PEMNDP 9,1140,1991
oral
quail 		lethal dose (50 percent kill): >2,150 mg/kg N/R PEMNDP 9,1140,1991
oral
rat 		lethal dose (50 percent kill): 365 mg/kg N/R PEMNDP 9,1140,1991
skin
rat 		lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,1140,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 15 gm/kg/13 week- intermittent Eye: Conjunctiva irritation

Liver: Other changes

Blood: Changes in leukocyte (WBC) count 		NTIS** OTS0537618
oral
dog 		lowest published toxic dose: 14 gm/kg/4 week- intermittent Behavioral: Tremor

Behavioral: Ataxia

Blood: Changes in leukocyte (WBC) count 		NTIS** OTS0537619
oral
mouse 		lowest published toxic dose: 23,520 mg/kg/7 week- continuous Liver: Hepatitis (hepatocellular necrosis), diffuse

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0540967
oral
rat 		lowest published toxic dose: 36,400 mg/kg/1 year- continuous Liver: Fatty liver degeneration

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0536968
oral
rat 		lowest published toxic dose: 4,550 mg/kg/13 week- continuous Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0537617
oral
rat 		lowest published toxic dose: 11,200 mg/kg/4 week- continuous Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Liver function tests impaired

Blood: Changes in platelet count 		NTIS** OTS0537620


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-

RTECS Compound Description:
   Agricultural Chemical

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