The Registry of Toxic Effects of Chemical Substances

Triethylenetetramine

RTECS #: YE6650000

CAS #: 112-24-3

UPDATE: November 2004 MW: 146.28 MF: C6H18N4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Trien
  2. Trientine
  3. Araldite hardener HY 951
  4. Araldite HY 951
  5. N,N - Bis (2 - aminoethyl) - 1,2 - diaminoethane
  6. N,N' - Bis (2 - aminoethyl) ethylenediamine
  7. DEH 24
  1. 3,6 - Diazaoctane - 1,8 - diamine
  2. 1,2 - Ethanediamine, N,N' - bis (2 - aminoethyl) -
  3. Ethylenediamine, N,N' - bis (2 - aminoethyl) -
  4. HY 951
  5. Tecza
  6. TETA
  7. 1,4,7,10 - Tetraazadecane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		49 mg severe UCDS** 12/12/1966
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,443,1986
skin
rabbit 		490 mg open irritation test severe UCDS** 12/12/1966
skin
rabbit 		5 mg/24 hour severe 85JCAE -,443,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis rat liver 10 µg/L MUREAV 320,31,1994
mutation in microorganisms Salmonella typhimurium 500 nmol/plate (+enzymatic activation step) MUREAV 88,165,1981
mutation in microorganisms Salmonella typhimurium 100 µg/plate (-enzymatic activation step) ENMUDM 8(Suppl 7),1,1986
sister chromatid exchange hamster ovary 1 mg/L MUREAV 320,31,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 9,130 mg/kg (1-22 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Other developmental abnormalities 		LANCAO 1,1127,1982
oral
rat 		lowest published toxic dose: 17,430 mg/kg (1-21 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		PSEBAA 173,598,1983
oral
rat 		lowest published toxic dose: 8,715 mg/kg (1-21 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Homeostasis 		PSEBAA 173,598,1983
skin
guinea pig 		lowest published toxic dose: 3,667 mg/kg (10-56 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death AITEAT 22,123,1974


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 468 mg/kg N/R ARTODN 61,321,1988
intravenous
mouse 		lethal dose (50 percent kill): 350 mg/kg N/R EJMCA5 19,425,1984
oral
mouse 		lethal dose (50 percent kill): 1,600 mg/kg N/R KHZDAN 22,179,1979
oral
rat 		lethal dose (50 percent kill): 2,500 mg/kg N/R 37ASAA 7,580,1979
oral
rabbit 		lethal dose (50 percent kill): 5,500 mg/kg N/R KHZDAN 22,179,1979
skin
rabbit 		lethal dose (50 percent kill): 805 mg/kg N/R JIHTAB 31,60,1949


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JJOMDZ 15,808,1973
TOXICOLOGY REVIEW
CTOXAO 12,601,1978
TOXICOLOGY REVIEW
MUREAV 488,151,2001


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - POLAND time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 1 ppm (6 mg/m3), KTV 2 ppm (12 mg/m3), JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82037;
Number of Industries 37;
Total Number of Facilities 1,982;
Number of Occupations 44;
Total Number of Employees Exposed 14,389
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82037;
Number of Industries 96;
Total Number of Facilities 7,057;
Number of Occupations 88;
Total Number of Employees Exposed 165,511;
Total Number of Female Employees Exposed 20,726


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate for adhesives, fungicides, asphalt additives and emulsifiers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Triethylenetetramine, 2540
OSHA ANALYTICAL METHOD #ID-60


REFERENCES:

CODEN
REFERENCE
37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as intermediate for adhesives, fungicides, asphalt additives and emulsifiers

NIOSH PROFILE (AMINES, POLY), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Primary Irritant

ALT CAS #: 39421-77-7
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