The Registry of Toxic Effects of Chemical Substances

s - Trioxane, 2,4,6 - trimethyl -

RTECS #: YK0525000

CAS #: 123-63-7

UPDATE: October 1997 MW: 132.18 MF: C6H12O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2,4,6 - Trimethyl - s - trioxane
  2. Acetaldehyde, trimer
  3. Elaldehyde
  4. Paraacetaldehyde
  5. Paracetaldehyde
  6. Paral
  7. Paraldehyd (German)
  8. Paraldeide (Italian)
  1. PCHO
  2. RCRA waste number U182
  3. Triacetaldehyde (French)
  4. 2,4,6 - Trimethyl - 1,3,5 - trioxaan (Dutch)
  5. 2,4,6 - Trimethyl - 1,3,5 - trioxane
  6. s - Trimethyltrioxymethylene
  7. 2,4,6 - Trimetil - 1,3,5 - triossano (Italian)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 mg severe UCDS** 3/24/1970
skin
rabbit 		500 mg open irritation test mild UCDS** 3/24/1970


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 4,000 ppm/4 hour N/R UCDS** 3/24/1970
intramuscular
man 		lowest published toxic dose: 568 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate increased without fall in BP

Biochemical: Metabolism (intermediary): Other 		BJPYAJ 149,650,1986
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,257 mg/kg N/R JPETAB 119,19,1957
intraperitoneal
rat 		lowest published lethal dose: 2,100 mg/kg N/R TXAPA9 1,156,1959
oral
cat 		lowest published lethal dose: 3,300 mg/kg N/R HBAMAK 4,1289,1935
oral
mouse 		lethal dose (50 percent kill): 2,750 mg/kg N/R JPETAB 119,19,1957
oral
rat 		lethal dose (50 percent kill): 1,530 mg/kg N/R UCDS** 3/24/1970
oral
rabbit 		lethal dose (50 percent kill): 3,304 mg/kg N/R PSEBAA 29,730,1932
rectal
man 		lowest published lethal dose: 333 mg/kg Gastrointestinal: Necrotic changes SAMJAF 29,1021,1955
subcutaneous
rat 		lowest published lethal dose: 1,650 mg/kg N/R AEPPAE 182,348,1936
skin
rabbit 		lethal dose (50 percent kill): 14,100 µL/kg N/R UCDS** 3/24/1970
unreported route
man 		lowest published lethal dose: 1,462 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CLCHAU 19,361,1973
TOXICOLOGY REVIEW
FNSCA6 2,67,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1332;
Number of Industries 1;
Total Number of Facilities 48;
Number of Occupations 5;
Total Number of Employees Exposed 2,152;
Total Number of Female Employees Exposed 1,499


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a hypnotic agent and in the manufacture of organic compounds
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
BJPYAJ British Journal of Psychiatry. (Headley Brothers, Ltd., Ashford, Kent TN24 8HH, UK) V.109- 1963-
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-
FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR.
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
SAMJAF South African Medical Journal. (Medical Assoc. of South Africa, Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as a hypnotic agent and in the manufacture of organic compounds

RTECS Compound Description:
   Drug
   Human Data
   Primary Irritant

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