The Registry of Toxic Effects of Chemical Substances

Uracil, 5 - bromo - 3 - sec - butyl - 6 - methyl -

RTECS #: YQ9100000

CAS #: 314-40-9

UPDATE: November 2004 MW: 261.15 MF: C9H13BrN2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. (+ - ) - Bromacil
  2. 3 - sek.Butyl - 5 - brom - 6 - methyluracil (German)
  3. 5 - Bromo - 3 - sec - butyl - 6 - methyluracil
  4. 5 - Bromo - 6 - methyl - 3 - (1 - methylpropyl) - 2,4 (1H,3H) - pyrimidinedione
  5. 5 - Bromo - 6 - methyl - 3 - (1 - methylpropyl) uracil
  6. Borea
  7. Bromacil
  8. Bromacil (ACGIH)
  9. Bromax
  10. Bromazil
  11. Cynogan
  12. Du Pont herbicide 976
  13. Eerex Granular Weed Killer
  14. Eerex Water Soluble Concentrate Weed Killer
  1. Herbicide 976
  2. Hyvar X
  3. Hyvar X Weed Killer
  4. Hyvar X bromacil
  5. Hyvar X - L
  6. Hyvar X - WS
  7. Hyvarex
  8. Krovar II
  9. Nalkil
  10. Urox B
  11. Urox B water soluble concentrate weed killer
  12. Urox HX granular weed killer
  13. Urox - HX


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in mammalian somatic cells mouse lymphocyte 750 mg/L NTIS** PB84-138973
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		2,000 ppm JPFCD2 15,867,1980
sex chromosome loss and nondisjunction Neurospora crassa 10 mg/L MUREAV 167,35,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 38 mg/m3/2 hour (7-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** PB277-077


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >4,800 mg/m3 N/R PEMNDP 9,93,1991
oral
dog 		lethal dose : >5 gm/kg N/R TXAPA9 34,189,1975
oral
mouse 		lethal dose (50 percent kill): 3,040 mg/kg N/R JPFCD2 15,867,1980
oral
rat 		lethal dose (50 percent kill): 641 mg/kg N/R FAATDF 7,299,1986
skin
rat 		lethal dose (50 percent kill): >2,500 mg/kg N/R FAATDF 7,299,1986
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R PEMNDP 9,93,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 10,350 mg/kg/2 week- intermittent Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 34,189,1975
oral
rat 		lowest published toxic dose: 45,625 mg/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 34,189,1975


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,92,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (10 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (11 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (10 mg/m3), short term exposure limit 3 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (10 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (10 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm (11 mg/m3), STE;
2 ppm (22 mg/m3), SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BROMACIL-air 10 hour time-weighted average 1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80830;
Number of Industries 11;
Total Number of Facilities 362;
Number of Occupations 5;
Total Number of Employees Exposed 1,905
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80830;
Number of Industries 7;
Total Number of Facilities 755;
Number of Occupations 6;
Total Number of Employees Exposed 4,372;
Total Number of Female Employees Exposed 63


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
Used for general weed or brush control in noncrop areas and against perennial grasses
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used for general weed or brush control in noncrop areas and against perennial grasses

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector

ALT CAS #: 154670-12-9
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