The Registry of Toxic Effects of Chemical Substances

Uranium

RTECS #: YR3490000

CAS #: 7440-61-1

UPDATE: November 2004 MW: 238.00 MF: U


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Uranium (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
unreported route
rat 		lethal dose (50 percent kill): 750 mg/kg N/R GISAAA 37(10),27,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m3;short term exposure limit 0.6 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
HXPHAU 36,165,1973
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg/m3 DTLVS* 3,274,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.05 mg(U)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.25 mg(U)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 mg(U)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.25 mg(U)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, short term exposure limit 0.5 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.2 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.25 mg/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.2 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.25 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.015 mg/m3, MAC(short term exposure limit) 0.12 mg/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.075 mg/m3, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.015 mg/m3, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.075 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 mg/m3, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.05 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.2 mg(U)/m3, short term exposure limit 0.6 mg(U)/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO URANIUM, insol-air Carcinogen;
10 hour time-weighted average 0.2 mg/m3;
short term exposure limit 0.6 mg/m3 		NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO URANIUM, soluble compounds-air Carcinogen;
10 hour time-weighted average 0.05 mg/m3 		NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/163362)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in nuclear fission power plants
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HXPHAU Handbuch der Experimentellen Pharmakologie. (Berlin, Ger.) New series: V.1-49, 1935-78. For publisher information, see HEPHD2.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used in nuclear fission power plants

NIOSH PROFILE (URANIUM AND ITS COMPOUNDS), SRC, 4/78

ALT CAS #: 24678-82-8
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