The Registry of Toxic Effects of Chemical Substances

Urea, 3 - (p - chlorophenyl) - 1 - methoxy - 1 - methyl -

RTECS #: YS6425000

CAS #: 1746-81-2

UPDATE: April 2002 MW: 214.67 MF: C9H11ClN2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Aresin
  2. Arezin
  3. Arezine
  4. Urea, N' - (4 - chlorophenyl) - N - methoxy - N - methyl -
  5. 3 - (4 - Chlorphenyl) - 1 - methoxy - 1 - methylharnstoff (German)
  1. N - (4 - Chlorophenyl) - N' - methoxy - N - methylurea
  2. 3 - (4 - Chlorophenyl) - 1 - methoxy - 1 - methylurea
  3. HOE 2747
  4. Monolinuron


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 8 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		ARTODN 38,261,1977
oral
mouse 		lowest published toxic dose: 8 gm/kg (6-15 day pregnant) Reproductive: Other developmental abnormalities ARTODN 38,261,1977
oral
mouse 		lowest published toxic dose: 4 gm/kg (10-13 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ARTODN 38,261,1977
oral
mouse 		lowest published toxic dose: 1 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) ARTODN 38,261,1977


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
chicken 		lethal dose (50 percent kill): 138 mg/kg N/R RREVAH 77,126,1981
intraperitoneal
rat 		lethal dose (50 percent kill): 459 mg/kg N/R RREVAH 77,126,1981
oral
cat 		lethal dose (50 percent kill): 63 mg/kg Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		RREVAH 77,123,1981
oral
chicken 		lethal dose (50 percent kill): 242 mg/kg N/R RREVAH 77,126,1981
oral
dog 		lethal dose (50 percent kill): 500 mg/kg N/R 28ZEAL 5,158,1976
oral
rat 		lethal dose (50 percent kill): 1,800 mg/kg N/R WRPCA2 9,119,1970
subcutaneous
mouse 		lethal dose (50 percent kill): 2,645 mg/kg N/R RREVAH 77,127,1981
subcutaneous
rat 		lethal dose (50 percent kill): 1,093 mg/kg N/R RREVAH 77,127,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 113 mg/kg/90 day- continuous Blood: Normocytic anemia RREVAH 77,131,1981
oral
rat 		lowest published toxic dose: 900 mg/kg/90 day- continuous Blood: Normocytic anemia RREVAH 77,131,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
DTTIAF 80,485,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a pre-emergence herbicide
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as a pre-emergence herbicide

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector

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