The Registry of Toxic Effects of Chemical Substances

2,6 - Xylidine

RTECS #: ZE9275000

CAS #: 87-62-7

UPDATE: August 2003 MW: 121.20 MF: C8H11N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Amino - 2,6 - dimethylbenzene
  2. 2,6 - Dimethylaniline
  3. 2,6 - Dimethylbenzenamine
  4. 2,6 - Dimethylphenylamine
  5. 2,6 - Xylylamine
  6. 2 - Amino - 1,3 - dimethylbenzene
  1. 2 - Amino - 1,3 - xylene
  2. 2 - Amino - m - xylene
  3. Aniline, 2,6 - dimethyl -
  4. DMA
  5. NCI - C56188


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 1 gm/L EMMUEG 10(Suppl 10),1,1987
mutation in microorganisms Salmonella typhimurium 50 µmol/plate (-enzymatic activation step) JAFCAU 34,157,1986
phage inhibition capacity Escherichia coli 39 µg/well MUREAV 260,349,1991
sister chromatid exchange hamster ovary 301 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 107 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Tumors 		NTPTR* NTP-TR-278,1990
oral
rat 		lowest published toxic dose: 27,846 mg/kg/26 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Tumorigenic: Facilitates action of known carcinogens 		TOPADD 15,39,2002
oral
rat 		lowest published toxic dose: 131,040 mg/kg/104 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		NTIS** PB90-256363
oral
rat 		lowest published toxic dose: 109,200 mg/kg/104 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Liver: Tumors 		NTIS** PB90-256363
oral
rat 		lowest published toxic dose: 65,520 mg/kg/52 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Tumorigenic: Facilitates action of known carcinogens 		CALEDQ 142,161,1999


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 707 mg/kg N/R NTIS** PB214-270
oral
rat 		lethal dose (50 percent kill): 840 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Blood: Changes in spleen 		TXAPA9 22,153,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 3,150 mg/kg/20 day- continuous Blood: Changes in spleen FAATDF 3,285,1983
oral
rat 		lowest published toxic dose: 6,200 mg/kg/2 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-278,1990
oral
rat 		lowest published toxic dose: 13,300 mg/kg/4 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		TXCYAC 12,63,1979
oral
rat 		lowest published toxic dose: 20,150 mg/kg/13 week- intermittent Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Blood: Changes in other cell count (unspecified) 		NTPTR* NTP-TR-278,1990
oral
rat 		lowest published toxic dose: 6 gm/kg/4 week- continuous Eye: Other eye effects JTSCDR 25,105,2000
oral
rat 		lowest published toxic dose: 5,600 mg/kg/4 week- intermittent Olfaction: Other olfaction effects JTSCDR 25,105,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 57,323,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 57,323,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 57,323,1993


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (2.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (10 mg/m3), Skin, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 10 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (10 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 ppm (10 mg/m3), short term exposure limit 10 ppm, Skin, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7951;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 5;
Total Number of Employees Exposed 4,354;
Total Number of Female Employees Exposed 729


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate for manufacture of pesticides, dyestuffs, antioxidants, pharmaceuticals
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:rat


REFERENCES:

CODEN
REFERENCE
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as intermediate for manufacture of pesticides, dyestuffs, antioxidants, pharmaceuticals

RTECS Compound Description:
   Tumorigen
   Mutagen
   Natural Product

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