NIOSH Pocket Guide to Chemical Hazards


CAS 106-49-0


RTECS XU3150000
Synonyms & Trade Names
4-Aminotoluene, 4-Methylaniline, 4-Methylbenzenamine, 4-Toluidine, p-Tolylamine
DOT ID & Guide
1708 153


NIOSH REL: Ca See Appendix A
OSHA PEL†: none
IDLH Ca [N.D.] See: IDLH INDEX Conversion
Physical Description
White solid with an aromatic odor. [Note: Used as a basis for many dyes.]
MW: 107.2
BP: 393°F
MLT: 111°F
Sol: 0.7%
VP(108°F): 1 mmHg
IP: 7.50 eV

Sp.Gr: 1.05
Fl.P: 188°F
UEL: ?
LEL: ?

Combustible Solid
Incompatibilities & Reactivities
Oxidizers, acids
Measurement Methods
NIOSH 2002; OSHA 73
See: NMAM or OSHA Methods
Personal Protection & Sanitation (See protection)
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated/Daily
Remove: When wet or contaminated
Change: Daily
Provide: Eyewash, Quick drench
First Aid (See procedures)
Eye: Irrigate immediately
Skin: Soap wash immediately
Breathing: Respiratory support
Swallow: Medical attention immediately
Important additional information about respirator selection
Respirator Recommendations NIOSH
At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having an N100, R100, or P100 filter. Click here for information on selection of N, R, or P filters./Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms Irritation eyes, skin; dermatitis; hematuria (blood in the urine), methemoglobinemia; cyanosis, nausea, vomiting, low blood pressure, convulsions; anemia, lassitude (weakness, exhaustion); [potential occupational carcinogen]
Target Organs Eyes, skin, blood, cardiovascular system

Cancer Site [in animals: liver tumors]
See also: INTRODUCTION   See ICSC CARD: 0343