NIOSH Pocket Guide to Chemical Hazards

Ethylene oxide

CAS 75-21-8

C2H4O

RTECS KX2450000
Synonyms & Trade Names
Dimethylene oxide; 1,2-Epoxy ethane; Oxirane
DOT ID & Guide
1040 119P

Exposure
Limits

NIOSH REL: Ca TWA <0.1 ppm (0.18 mg/m3) C 5 ppm (9 mg/m3) [10-min/day] See Appendix A
OSHA PEL: [1910.1047] TWA 1 ppm 5 ppm [15-minute Excursion]
IDLH Ca [800 ppm] See: 75218 Conversion 1 ppm = 1.80 mg/m3
Physical Description
Colorless gas or liquid (below 51°F) with an ether-like odor.
MW: 44.1
BP: 51°F
FRZ: -171°F
Sol: Miscible
VP: 1.46 atm
IP: 10.56 eV
RGasD: 1.49
Sp.Gr: 0.82 (Liquid at 50°F)
Fl.P: NA (Gas) -20°F (Liquid)
UEL: 100%
LEL: 3.0%

Flammable Gas
Incompatibilities & Reactivities
Strong acids, alkalis & oxidizers; chlorides of iron, aluminum & tin; oxides of iron & aluminum; water
Measurement Methods
NIOSH 1614, 3800; OSHA 30, 49, 50
See: NMAM or OSHA Methods
Personal Protection & Sanitation (See protection)
Skin: Prevent skin contact (liquid)
Eyes: Prevent eye contact (liquid)
Wash skin: When contaminated (liquid)
Remove: When wet (flammable)
Change: No recommendation
Provide: Quick drench (liquid)
First Aid (See procedures)
Eye: Irrigate immediately
Skin: Water flush immediately
Breathing: Respiratory support
Swallow: Medical attention immediately (liquid)
Important additional information about respirator selection
Respirator Recommendations (See Appendix E) NIOSH
Up to 5 ppm:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted canister providing protection against the compound of concern
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted canister providing protection against the compound of concern/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, ingestion (liquid), skin and/or eye contact
Symptoms Irritation eyes, skin, nose, throat; peculiar taste; headache; nausea, vomiting, diarrhea; dyspnea (breathing difficulty), cyanosis, pulmonary edema; drowsiness, lassitude (weakness, exhaustion), incoordination; EKG abnormalities; eye, skin burns (liquid or high vapor concentration); liquid: frostbite; reproductive effects; [potential occupational carcinogen]; in animals: convulsions; liver, kidney damage
Target Organs Eyes, skin, respiratory system, liver, central nervous system, blood, kidneys, reproductive system

Cancer Site [peritoneal cancer, leukemia]
See also: INTRODUCTION   See ICSC CARD: 0155   See MEDICAL TESTS: 0106